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Gabapentin is an uncommon cause of DILI reported to cause a hepatocellular, cholestatic, or mixed picture of liver injury. Given the limitations of prior cases, we feel our report most closely ties gabapentin use to the resultant transaminase elevation. Gabapentin, a gamma-aminobutyric acid (GABA) analogue, is not known to cause liver or kidney problems. However, it can cause an allergic reaction called DRESS syndrome, which can lead to liver or kidney damage. Prior lab review showed liver enzymes within normal limits until one month prior to admission, when his ALP was 851. He started taking gabapentin, without introduction of any other medications, one month prior to the initial rise in ALP . Evaluation for viral, inherited, and metabolic causes of liver disease were negative. To minimize the risk of liver damage while taking Gabapentin, it is important to follow these guidelines: Inform your healthcare provider about any pre-existing liver conditions or medications you are taking. Regularly monitor liver function through blood tests as recommended by your doctor. Gabapentin-Induced Liver ToxicityAm J Ther. 2022 Nov-Dec;29 (6):e751-e752. doi: 10.1097/MJT.0000000000001208. Epub 2020 Jun 5. Medications like Tylenol and Aleve are hepatotoxic, meaning they could raise liver enzymes and damage your liver over time. See the list of medications to avoid. Liver toxicity is not a common side effect of gabapentin. However, in rare cases, individuals with pre-existing liver conditions or those taking other liver-damaging medications may experience an increased risk of liver-related side effects. In rare cases, gabapentin can cause liver and kidney damage in dogs. Dogs with pre-existing liver or kidney disease may be more susceptible to these side effects. Gabapentin was reported to cause cholestasis in two case reports. Despite the small number of reported cases of hepatotoxicity, trazodone and gabapentin are known causes of liver injury, and clinicians should be aware of this possibility. Can gabapentin cause liver enzymes to be elevated? Gabapentin is a unique anticonvulsant used as an adjunctive therapy in managing epilepsy and neuropathic pain syndromes. It is a structural analogue of gamma-aminobutyric acid (GABA) and has been approved for use in the United States in 1993. It is used as an anticonvulsant and neuropathy agent, with over 18 million prescriptions filled I found online somewhere that Gabapentin can inflame the liver, yet, also read that it is not metabolized in the liver at all. I read that incidents of liver problems are less than one percent as stated by Pfizer. Gabapentin, a water-soluble amino acid, is eliminated unchanged by the kidneys and there is no appreciable metabolism by the liver. However, there are a few descriptions of gabapentin-related Gabapentin is eliminated through the kidneys and, therefore, doesn’t typically cause liver injury. Learn safe dosage recommendations for people with liver disease. Gabapentin is not metabolized by the liver. Instead, it is excreted unchanged in your kidneys after circulating in your blood. Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. Though gabapentin has many potential uses, it can cause side effects. Read more about 13 gabapentin side effects here. Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. In our patient there was a clear temporal association of liver injury occurring after our patient began gabapentin therapy, and slight improvement after a few days of discontinuation. Although further studies on this topic are needed, gabapentin should be considered as a cause of drug induced liver injury. Gabapentin, a common over-the-counter pain reliever and fever reducer, has been linked to rare individual case reports of liver injury. The causal relationship between gabapentin and liver damage is unclear, with the latency to onset being 1 to 8 weeks. Gabapentin is generally considered safe for the liver, but rare cases of liver damage have been reported. Gabapentin, a medication primarily used to treat nerve pain and seizures, has gained popularity for its effectiveness and relatively mild side effects.
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