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Medications that cause weight gain, such as Zyprexa, Paxil, or gabapentin, can promote weight gain that can make you more likely to develop sleep apnea. If you already have OSA, that additional weight can worsen your symptoms and make the condition more severe. Sleep apnea syndrome is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Xyrem, and have Narcolepsy. Up to July 2018, Vigibase contained 76 reported sleep apnea (cases) for gabapentin and 123 for pregabalin. The majority of reported sleep apnea (cases) attributed to exposure to gabapentinoids originated from the United States (87%) and was reported after 2013 (58%). Abstract Medication-induced central sleep apnea (CSA) is one of the eight categories of causes of CSA but in the absence of awareness and careful history may be misclassified as primary CSA. While opioids are a well-known cause of respiratory depression and CSA, non-opioid medications including sodium oxybate, baclofen, valproic acid, gabapentin, and ticagrelor are less well-recognized Abstract Medication-induced central sleep apnea (CSA) is one of the eight categories of causes of CSA but in the absence of awareness and careful history may be misclassified as primary CSA. While opioids are a well-known cause of respiratory depression and CSA, non-opioid medications including sodium oxybate, baclofen, valproic acid, gabapentin, and ticagrelor are less well-recognized We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. A double-blind, randomized, placebo-controlled cross-over pilot study using a bedtime dose of gabapentin 300 mg was conducted in eight non-obese older men. Polysomnography measured the effects of the intervention. Understanding how gabapentin may affect sleep patterns is crucial in assessing its impact on sleep apnea symptoms and overall sleep quality. Gabapentin has been shown to influence sleep architecture in several ways. Keskindag B and Karaaziz M (2017) The association between pain and sleep in fibromyalgia. Saudi Med J 38: 465-475. [Crossref] Piovezan RD, Kase C, Moizinho R, Tufik S, Poyares D (2017) Gabapentin acutely increases the apnea-hypopnea index in older men: data from a randomized, double-blind, placebo-controlled study. J Sleep Res 26: 166-170 Central sleep apnea (CSA) in adults encompasses a group of sleep-related breathing disorders, categorized into six distinct entities in the third edition o Research suggests that gabapentin may potentially contribute to the development or worsening of sleep apnea symptoms in some individuals. While the exact mechanism is not fully understood, it is believed that gabapentin can affect the central nervous system and respiratory muscles, leading to disruptions in normal breathing patterns during sleep. We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. A double-blind, randomized, placebo-controlled cross-over pilot study using a bedtime dose of gabapentin 300 mg was conducted in eight non-obese older men. One trial showed that using pregabalin alone and using it with an opioid pain reliever can depress breathing function.7,8 The other trial showed gabapentin alone increased pauses in breathing In an August 2021 correspondence, she stated that she strongly concurs with Dr. W.K.R.'s above-mentioned statements, and opined that the Veteran's medications, cyclobenzaprine and gabapentin are strong culprits of the Veteran's obstructive sleep apnea diagnosis. Sleep apnea is a sleeping disorder marked by interruptions in breathing during sleep. Certain medications, such as antihistamines, benzodiazepines, barbiturates, and opiates, can impact your natural sleeping cycle and breathing. The other trial showed gabapentin alone increased pauses in breathing during sleep. The three observational studies at one academic medical center showed a relationship between gabapentinoids given before surgery and respiratory depression occurring after different kinds of surgeries. On one hand, gabapentin may alleviate conditions like restless legs syndrome that can exacerbate sleep disturbances. On the other hand, its sedative properties could potentially worsen respiratory depression in individuals with pre-existing sleep apnea, leading to more frequent and prolonged breathing pauses during sleep. We hypothesized that gabapentinoids might be associated with sleep apnea syndrome. A recent pilot study reported a higher apnea–hypopnea index with gabapentin, supporting our hypothesis [5]. What is Sleep Apnea? OSA is a sleep disorder where the airway becomes partially or completely blocked during sleep, leading to breathing interruptions. Sleep apnea can disrupt a person’s entire life, leading to a host of deleterious health outcomes, including heart attack and stroke. Sleep apnea afflicts millions globally. Obstructive sleep apnoea (OSA) is characterized by repeated episodes of apnoea and hypopnoea during sleep. Little is known about the potential impact of therapy drugs on the underlying respiratory disorder. Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. The objective of this systematic review and meta-analysis was to asse
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