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Drug interactions are reported among people who take Clonidine (clonidine) and Gabapentin (gabapentin). Common drug interactions include vomiting among females and drug ineffective among males. Using cloNIDine together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Compare Clonidine vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. A Moderate Drug Interaction exists between Catapres and gabapentin. View detailed information regarding this drug interaction. If you take clonidine (Catapres) for high blood pressure, it’s best to avoid alcohol and use caution with beta blockers like metoprolol. See more clonidine interactions here. Gabapentin and clonidine were concomitantly administered in a fixed-dose ratio proportional to the predetermined ED 50 of these drugs, thereby obtaining a dose–response curve for the drug combination and its ED 50. The profile of the interaction between these drugs was analyzed using an isobolographic analysis. See the list of drugs that interact with Gabapentin. Includes information on severity of interaction and the level of evidence for it. See the list of drugs that interact with Clonidine. Includes information on severity of interaction and the level of evidence for it. When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another Clonidine’s ability to reduce sleep latency and increase total sleep time may be enhanced by gabapentin’s promotion of slow-wave sleep and reduction of nighttime awakenings. To answer your first question, I did find that there are (moderately unsafe) interactions between Clonidine and Gabapentin (so it wouldn't be wise to take a full dose of each one together). Information that I've gathered on this states the following: 378 medications are known to interact with clonidine. Includes gabapentin, prednisone, metoprolol. A Moderate Drug Interaction exists between Clonidine ER and gabapentin. View detailed information regarding this drug interaction. Both oral clonidine and gabapentin are effective in obtunding pressor response to direct laryngoscopy, clonidine being better in terms of controlling HR. Gabapentin produces more postoperative sedation than clonidine. This research showed a significant difference between the clonidine + gabapentin group and with gabapentin group in terms of neuropathic pain and the severity of neuropathic pain (P < 0.001). According to this research results, clonidine + gabapentin can reduce neuropathic pain and the severity of neuropathic pain in diabetic patients. Mixing melatonin with clonidine can increase the sedative effect and lead to possible oversedation. Gabapentin (Neuraptine) Gabapentin is an anticonvulsant medication used to treat seizures, neuropathic pain, hot flashes, and restless leg syndrome. Gabapentin is sold under the brand name Neurontin. A Moderate Drug Interaction exists between Duraclon and gabapentin. View detailed information regarding this drug interaction. 378 medications are known to interact with Clonidine ER. Includes gabapentin, prednisone, metoprolol. Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine the effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients. In our study, we found that both clonidine and gabapentin are effective premedicants by oral route 2 h before induction of anesthesia to blunt the hemodynamic response to laryngoscopy and intubation as compared to placebo.
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