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Approximately 18% of people prescribed gabapentin for pain may abuse the drug. Being single, living alone, drinking alcohol, using nicotine, and taking antidepressants increase the risk of gabapentin misuse. Although evidence is currently scarce, anecdotal reports indicate that gabapentin misuse is possible in certain populations. The first reported case of gabapentin misuse in the literature involved a 42-year-old woman who had been dependent upon crack cocaine for at least twelve months. The abuse potential of gabapentin is well documented; with gabapentin having been noted as an agent highly sought after for use in potentiating opioids. When combined with opioids, the risk of respiratory depression and opioid-related mortality Epidemiological and case report evidence suggests that the antiepileptic and analgesic medication gabapentin is being misused internationally at a rate of about 1%, with substance abuse populations at special risk for misuse/abuse. This review summarizes current evidence on the abuse and misuse of the gabapentinoids pregabalin and gabapentin. Pharmacovigilance studies, register-based studies, surveys, clinical toxicology studies, and forensic toxicology studies were identified Despite their inherent abuse potential, gabapentinoids (gabapentin and pregabalin) may be safer than presumed and offer prescribers an effective opioid-alternative treatment for certain types of neuropathic pain. Gabapentin is an emerging drug of misuse Reports of gabapentin misuse are increasing. 3,4 Gabapentin can be misused orally, intranasally and intravenously, with doses ranging from therapeutic (< 3600 mg/d) to supratherapeutic (12 000 mg/d). 2 The exact prevalence of gabapentin misuse is unclear, as the current evidence is of low quality, relies on self-reports or has been derived from selected Two surveys reported that the misuse of gabapentin was 1.1% in the general population and 22% in drug abuse treatment centers. Withdrawal, when reported, occurred within 12 hours to 7 days of discontinuation of the medication. Conclusion: There have been numerous documented cases of gabapentin abuse, dependence, and withdrawal. Blair H Smith 1 University of Dundee; Peterhead Medical Practice, Aberdeenshire. E-mail: b.z.smith@dundee.ac.uk 2 Department of Psychiatry, University of Dundee 3 University of Dundee; Consultant Psychiatrist, Fife NHS Addiction Services 4 University of Dundee; Consultant Psychiatrist, Substance Misuse Service, NHS Tayside 5 University of Dundee; Consultant Pain Specialist, Pain Clinic Gabapentin (Neurontin) carries a risk for abuse, can get you high if mixed with drugs, causes adverse side effects, and can lead to overdose. Despite being widely considered safe when used as directed, gabapentin can cause serious harm when abused. People misuse this drug to experience calming or euphoric effects, often increasing their dosage or combining it with other substances like alcohol. Gabapentin is a seizure and nerve pain medication that has received national attention for its abuse potential. The prevalence of gabapentin misuse is about 1% among the general population, up to 65% among patients with a prescription for gabapentin, and up to 22% among people who used opiates. This page will discuss what gabapentin is, side effects of the drug, its misuse liability, symptoms of gabapentin addiction, gabapentin withdrawal, and how a gabapentin rehab program can help with addiction recovery. Unfortunately, the widespread use of gabapentinoid drugs has resulted in reports of misuse and abuse. Here we summarize the clinical reports of gabapentinoid abuse in different patient populations to help inform clinical practice of chronic pain management. Epidemiological and case report evidence suggests that the anti-epileptic and analgesic medication gabapentin is being misused internationally, with substance abuse populations at special risk for misuse/abuse. Though gabapentin was initially marketed as a medication with low potential for abuse and is commonly thought to be safe and effective, a growing body of evidence highlights the potential risks of overprescribing the medication. Here are several factors to keep in mind when considering gabapentin for your patients or working with patients who have been prescribed gabapentin by another doctor. The current work is targeted to review the risks of gabapentin misuse, its potential interactions with other drugs, side effects and use contraindications. This review consists of a total of 99 biographical references (from the year 1983 to 2016). A This review summarizes current evidence on the abuse and misuse of the gabapentinoids pregabalin and gabapentin. Pharmacovigilance studies, register-based studies, surveys, clinical toxicology studies, and forensic toxicology studies were identified and scrutinized with the goal to define the proble Gabapentin, an anticonvulsant medication, is generally considered to have a low risk profile for addiction, but some people may still misuse and abuse it to get high. Chronic gabapentin abuse can increase the risk of developing a gabapentin addiction.
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