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Abstract Purpose of review: Gabapentinoid use has increased substantially in the past several years after initial promising data with regard to acute perioperative pain control. The purpose of this review is to critically appraise the evidence for the use of gabapentinoids for acute pain management and its impact on the development of chronic pain after surgery. Abstract Neuropathic pain after spinal surgery, the so-called failed back surgery syndrome (FBSS), is a frequently observed troublesome disease entity. Although medications may be effective to some degree, many patients continue experiencing intolerable pain and functional disability. Only gabapentin has been proven effective in patients with FBSS. No relevant studies regarding manipulation or This systematic review and network meta-analysis evaluates the associations of pain, opioid consumption, and adverse events with different dosages of pregabalin and gabapentin in patients undergoing spine surgery. Peng C, Li C, Qu J, Wu D. Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. While the use of gabapentin may reduce pain and spare opioids in younger populations, the risks in older adults do not seem to outweigh the benefits. As a health care system, we need to strategize more broadly about pain control after surgery. Making progress in this complex clinical space is not easy, but improvements are achievable. Conclusion Gabapentin, pregabalin, and duloxetine have potential to further decrease post-operative pain and lower opioid dependency. This review creates an opening for further research in hand surgery to assess an updated protocol for pain management to reduce opioid dependency. Factors Influencing Duration of Gabapentin Use Several factors come into play when determining how long gabapentin should be taken after surgery. First off, the type and extent of the surgical procedure significantly influence recovery time and pain levels. Outcomes and Data Analyses The primary outcome is prolonged use of gabapentin in the postoperative period, defined as a prescription refilled at 90-180 days after discharge from surgery, a time period based on definitions of prolonged use of opioids after surgical procedures. 20, 25, 26 We calculated the days’ supply and average daily dose. They showed that oral gabapentin was efficacious in the management of postoperative pain at every time point during the first day after surgery and therefore is efficacious in reducing postoperative pain and narcotic requirements after lumbar spinal surgery [49]. Preoperative oral gabapentin decreased pain scores in the early postoperative period and postoperative morphine consumption in spinal surgery patients while decreasing some morphine-associated side effects. Perioperative gabapentin upped the risk of delirium, new antipsychotic use, and pneumonia in older adults after major surgery, a retrospective study showed. Risk of delirium -- the primary outcome Abstract Perioperative pain management is a unique challenge in patients undergoing spine surgery due to the increased incidence of both pre-existing chronic pain conditions and chronic postsurgical pain. Peri-operative planning and counseling in spine surgery should involve an interdisciplinary approach that includes consideration of patient-level risk factors, as well as pharmacologic and Additionally, more evidence is emerging, and it is necessary to re-evaluate the efficacy and safety of gabapentin for pain control after spinal surgery. This meta-analysis aimed to evaluate whether gabapentin can decrease pain intensity, total morphine consumption and related complications, and whether high-dose gabapentin is superior to low SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative The results from this study demonstrate that gabapentin is more beneficial in mastectomy and spinal, abdominal, and thyroid surgeries. Gabapentin is an effective analgesic adjunct, and clinicians should consider its use in multimodal treatment plans among patients undergoing elective surgery. Gabapentin may be prescribed either before or after surgery to help with postsurgical pain. However, it should be used with caution due to the high risk of abuse. This randomized clinical trial evaluates the effects of perioperative administration of gabapentin on postoperative pain resolution and time to cessation of opioid use. A systematic review and meta-analysis of 27 RCTs of adults undergoing spine surgery compared postoperative pain control, safety outcomes, and opioid consumption associated with different perioperative doses of gabapentin and pregabalin. Gabapentin 900 mg per day before spine surgery may be an effective and safe option for reducing postsurgical pain and opioid consumption. Nerve Pain Medication: In some cases, medications like gabapentin (Neurontin) or pregabalin (Lyrica) may be prescribed to manage nerve pain (neuropathic pain) that can occur after spine surgery. Opioids: These are potent pain relievers that may be prescribed for moderate to severe pain following spine surgery. Would you want to take Lyrica (pregabalin) or Neurontin (gabapentin) for pain relief after a major surgery? Both drugs belong to a class of nerve medication called gabapentinoids that are increasingly being prescribed to patients perioperatively (after surgery) as an alternative to opioid medication.
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