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Postoperative pain management remains a significant challenge for patients undergoing abdominal surgery, with poorly managed pain adversely affecting recovery, leading to increased opioid use and associated side effects. Gabapentin, an Purpose Gabapentin has demonstrated analgesic effects in some studies. This double blind randomized clinical trial (RCT) was conducted to evaluate whether the pre-emptive use of gabapentin 600 mg could reduce postoperative pain, nausea and vomiting, and meperidine consumption in patients after hysterectomy. Methods Between 2009 and 2010, a total of 170 patients who were candidates for Pain management after total knee arthroplasty (TKA) varies and has been widely studied in recent years. Some randomized controlled studies have carried out to evaluate the effects of gabapentin on pain relief after TKA. However, no solid result was Pre-emptive use of gabapentin 600 mg orally, significantly decreases postoperative pain and PONV, and also rescues analgesic and anti emetic drug requirements in patients who undergo abdominal hysterectomy. We manually searched the reference lists of identified studies. Methods of study selection: Randomized controlled trials of women who underwent a total abdominal hysterectomy, with or without bilateral salpingo-oophorectomy, under general anesthesia were examined. Only trials with preoperative dose of gabapentin were included. Outcomes and Data Analyses The primary outcome is prolonged use of gabapentin in the postoperative period, defined as a prescription refilled at 90-180 days after discharge from surgery, a time period based on definitions of prolonged use of opioids after surgical procedures. 20, 25, 26 We calculated the days’ supply and average daily dose. Keywords: Gabapentin, Pain Postoperative, Tramadol, Hysterectomy, Analgesia, Preanesthetic Medication 1. Background One of the main concerns that patients deal with surgery is pain after. Nowadays, treating postoperative pain is highly regarded. Pain, nausea vomiting and drowsiness are the most common causes of delayed recovery (1). A single dose of 300 mg pregabalin given 1–2 hours prior to surgery is superior to 900 mg gabapentin and placebo after abdominal hysterectomy. Both the drugs are better than placebo. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathic pain as well as postoperative pain following spinal surgery and hysterectomy. Abstract We investigated, in a randomized, placebo-controlled, double-blind study, the efficacy and safety of gabapentin on pain after abdominal hysterectomy and on tramadol consumption in patients. The 50 patients were randomized to receive either oral placebo or gabapentin 1200 mg 1 h before surgery. Postoperative pain is an important factor affecting anesthesia and surgery. The present study assessed the effects of 1200 mg gabapentin, an anticonvulsant drug that acts through voltage-dependent calcium channels, for the control of postoperative Gabapentin, an anticonvulsant, has been proposed as an effective analgesic within enhanced recovery after surgery (ERAS) protocols to minimize opioid consumption and reduce postoperative nausea and vomiting (PONV). However, its role in perioperative pain management lacks consensus, necessitating a systematic review and meta-analysis. Methods Extract Summary Background and objective: Gabapentin has been suggested to decrease acute postoperative pain. We evaluated the effect of gabapentin on pain after abdominal hysterectomy. Methods: Sixty patients scheduled for abdominal hysterectomy were randomized to receive orally gabapentin 400 mg 6 hourly or placebo. The most common dose of gabapentin assessed was 1200 mg daily (12 studies), with some studies using doses as low as 300 mg daily (Table 1). Eleven studies (25, 28 – 33, 36, 38 – 40) administered gabapentin as a single dose within 1 h to 2 h before surgery; the remainder involved initiating therapy on the day before surgery or continuing it for up to 10 days after surgery (Table 1). With Overall, when choosing a preemptive nonnarcotic medication to control pain after abdominal hysterectomy, this review supports the use of an NSAID, COX-2 inhibitor, gabapentin, and/or paracetamol. Pain scores after abdominal hysterectomy were reduced more with gabapentin alone (preoperative dosing) than when gabapentin was given both preoperatively and postoperatively. The benefits of gabapentin for minimally invasive hysterectomy (MIH) are not as well defined. This randomized clinical trial evaluates the effects of perioperative administration of gabapentin on postoperative pain resolution and time to cessation of opioid use. Gabapentin may be prescribed either before or after surgery to help with postsurgical pain. However, it should be used with caution due to the high risk of abuse. Would you want to take Lyrica (pregabalin) or Neurontin (gabapentin) for pain relief after a major surgery? Both drugs belong to a class of nerve medication called gabapentinoids that are increasingly being prescribed to patients perioperatively (after surgery) as an alternative to opioid medication. For example, a gabapentin dose of 1.2 grams per day 1 hour before surgery and for 2 days after CABG surgery showed that postoperative pain scores at 1, 2, and 3 days as well as the consumption of tramadol given as a rescue analgesic were significantly lower in the gabapentin group when compared to the placebo group [41].
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