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Gabapentin has become increasingly popular for the treatment of chronic pain because it’s not nearly as addictive as opioids, researchers said in background notes. But concerns have been growing that gabapentin might contribute to cognitive decline, since it works by suppressing communication between nerve cells, researchers said. The first case is an 82-year-old male with Alzheimer's dementia, who had unsatisfactory treatment of agitation with trazodone and quetiapine 25mg twice daily. Subsequently, for over a month, he was treated with gabapentin on a gradual dose increase from 100mg twice daily to three times daily. The association of gabapentin use and change of cognitive and functional status in older adults with normal cognition GYeon Oh, University of Kentucky / Sanders-Brown Center on Aging, Lexington, KY, USA. The results from this study showed that gabapentin therapy was associated with decline in memory, executive function, and attention after 1 week of gabapentin treatment (Shem et al., 2018). Abstract Aim: To evaluate low dose gabapentin in treatment of disruptive behavioral symptoms in patients with moderate- severe dementia with Lewy bodies. Findings: Improvement in symptoms seen by clinician and caregivers supported by changes on respective scales. Over 1 or 2 years of follow-up, gabapentin initiation was not associated with decline in cognitive or functional status but was associated with increased odds of falling among research participants with cognitive impairment. Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. In clinical practice, the duration of gabapentin or pregabalin therapy mainly depends on the clinical symptoms and adverse effects of the treatment. After a literature review, we were unsure of the duration the drugs would require to cause the side effects of cognitive impairment or dementia. As we mentioned above, in most of the reviewed cases gabapentin is reported to be a well-tolerated and effective treatment for dementia-associated agitation. However, several case reports in which gabapentin was used for agitation in dementia with Lewy bodies question its appropriateness for all types of dementia-related agitation [14 – 16]. To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral The results from this study showed that gabapentin therapy was associated with decline in memory, executive function, and attention after 1 week of gabapentin treatment (Shem et al., 2018). To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia For these reasons, gabapentin has recently been included in treatment regimens for agitation in dementia patients [1], [11]. Data regarding the use of gabapentin in AD has been accumulating since 1997. Only a few case reports have shown the efficacy of pregabalin [4], [11]. Background Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. Howev Unraveling the Mystery: Does Gabapentin Contribute to Alzheimer’s Risk? As we delve into the complexities of brain health and cognitive function, one medication that often comes up in discussions is Gabapentin. Originally developed to treat epilepsy and neuropathic pain, Gabapentin has gained popularity for its off-label uses, including the management of anxiety and certain types of chronic Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and Preliminary low-grade evidence based on case series and case reviews suggests possible benefit of gabapentin and pregabalin in patients with BPSD in Alzheimer's disease. These benefits cannot be confirmed until well-powered randomized controlled trials are undertaken. Evidence in frontotemporal dementia is lacking. The first case is an 82-year-old male with Alzheimer's dementia, who had unsatisfactory treatment of agitation with trazodone and quetiapine 25mg twice daily. Subsequently, for over a month, he was treated with gabapentin on a gradual dose increase from 100mg twice daily to three times daily. A favorable sustained response was achieved as no additional as needed medications for agitation were The purpose of this review was to find evidence for the use of gabapentin in the treatment of BPSD. To this end, a search was performed for case reports, case series, controlled trials and reviews of gabapentin in the treatment of this condition. The key words 'dementia', 'Alzheimer's disease' and 'gabapentin' were used.
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