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A Moderate Drug Interaction exists between gabapentin and zonisamide. View detailed information regarding this drug interaction. Zonisamide Zonisamide has been shown to be both effective for focal and generalised seizures in people. It is metabolized mainly by hepatic microsomal enzymes, and the half-life in dogs is approximately 15 hours. The dose suggested for use as an add-on drug in dogs is 10 mg/kg q12hrs PO. Zonisamide has been used to a smaller degree in cats but seems to have more side effects than in dogs. Gabapentin is a drug that is used extensively for neuropathic pain, but also has anticonvulsant properties with the main mechanism of action likely through inhibition of voltage-gated calcium channels. In dogs, phenobarbital and bromide are considered first-line maintenance anticonvulsants; levetiracetam and zonisamide are often used as well. In cats, phenobarbital is the usual first choice; however, use of levetiracetam and zonisamide is becoming more common. No anticonvulsant is approved for use in large animals. Zonisamide Zonisamide has been shown to be both effective for focal and generalised seizures in people. It is metabolized mainly by hepatic microsomal enzymes, and the half-life in dogs is approximately 15 hours. The dose suggested for use as an add-on drug in dogs is 10 mg/kg q12hrs PO. Here are some relevant points: During the past 10 to 15 years, a number of new anticonvulsant drugs have been introduced for the treatment of human seizure disorders, some of which have been shown to be safe and effective for use in dogs. These drugs include gabapentin, felbamate, zonisamide and levitiracetam. Commonly used antiseizure medications in dogs and cats in the United States include bromide, levetiracetam, phenobarbital, and zonisamide. Other medications used for treatment of seizures in dogs and cats include cannabidiol, gabapentin, and topiramate. An effective epilepsy treatment plan for dogs should reduce seizure frequency, minimize adverse drug effects, and maximize quality of life. Overview The article describes seven effective medications for managing canine seizures: phenobarbital, potassium bromide, levetiracetam, zonisamide, gabapentin, diazepam, and felbamate, detailing their mechanisms, effectiveness, dosing guidelines, and potential side effects. With proper medication management and regular veterinary monitoring, most dogs with seizure disorders can lead full In dogs, however, 30–40% of the orally administered dose of gabapentin undergoes hepatic metabolism to N-methyl-gabapentin. Despite undergoing some hepatic metabolism in dogs, there is no appreciable induction of hepatic microsomal enzymes in this species. The t ½ for gabapentin in dogs and cats is between 3 and 4 hrs. The dose should be higher when zonisamide is used with phenobarbital. Over the years, the generic form has become more affordable, even for larger dogs. It is the drug of choice when the side effects seen with the previous anticonvulsant drugs are of concern for the pets and the client. Keppra® (levetiracetam). Zonegran (zonisamide) and gabapentin are anticonvulsants used to treat seizures in patients with epilepsy. Gabapentin is also used to treat nerve pain caused by shingles (herpes zoster). Zonisamide for Dogs: Insights into Zonisamide’s effectiveness for canine seizures, appropriate dosages, and side effects. 413 medications are known to interact with zonisamide. Includes gabapentin, sertraline, metformin. Thus, veterinary medicine is seeing an increase in the options available for managing refractory seizures in dogs. In this article, I discuss the potential use of five newer antiepileptic drugs: felbamate, gabapentin, pregabalin, zonisamide, and levetiracetam. What is zonisamide? Zonisamide (brand name: Zonegran®) is an anticonvulsant (antiseizure) medication that is used either as an initial therapy for epilepsy or as an add-on drug for seizures that are difficult to control. Its use in cats and dogs to treat seizures is “off label” or “extra label”. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these Alternative anticonvulsant drugs (AACDs) such as felbamate, 5 gabapentin, 4 levetiracetam, 3,6 pregabalin, 7 topiramate, and zonisamide 1 have shown promise for the management of veterinary seizure disorders, and their use is becoming more widespread in veterinary neurology. The seven medications reviewed—phenobarbital, potassium bromide, levetiracetam, zonisamide, gabapentin, pregabalin, and topiramate—offer veterinarians multiple options for tailoring treatment to each individual dog’s needs. Health Other Diseases Managing Idiopathic Epilepsy in Dogs Idiopathic epilepsy in dogs can be managed with one or more anticonvulsants, including phenobarbital, zonisamide, and levetiracetam. Learn more about the potential side effects of these medications and about other ways to manage seizures in dogs. Therefore, many dogs require increases in their phenobarbital dose over time to maintain the same level of seizure control. To help determine if a pet is receiving an appropriate dose of a medication, veterinarians may monitor the amount present in the bloodstream, a procedure that is called therapeutic drug monitoring.
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