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In this episode, host Alyssa Watson, DVM, is joined by Rebecca Reader, DVM, DACVAA, to talk about her recent Clinician’s Brief article, “ Top 5 Uses for Gabapentin in Dogs & Cats.” Dr. Reader sorts through the evidence to help us differentiate between all the ways gabapentin can be used and all the ways it should be used, which are far fewer. She also shares useful dosing details • Gabapentin may be the best available treatment for facilitating BP measurement in uncooperative or anxious cats or in cases in which an owner requests patient sedation; however, BP measure-ment in calm, cooperative, nonsedated cats is the best approach for obtaining reliable measurements. 2 References 1. Oral gabapentin in cats – often without additional sedation/premedication – can be used by house-call and clinic-bound veterinarians to facilitate examination, blood draws, cystocentesis and additional injections. Gabapentin is often used in dogs and cats to prevent seizures and treat neuropathic pain. Although gabapentin is a structural analog of the neurotransmitter gamma-aminobutyric acid (GABA), it appears not to interact with GABA receptors. Gabapentin is excreted unchanged in humans but is metabolized to N-methyl-gabapentin in dogs. Trusted content. Gabapentin, an anticonvulsant used in the treatment of neuropathic pain, has been shown to reduce anxiety in rats and humans. 1,2 Although gabapentin’s anxiolytic properties have not been studied in cats, pharmacokinetics studies have reported excellent oral bioavailability and a wide margin of safety with single-dose administration. 3 Discover how this protocol uses gabapentin, melatonin, and acepromazine to decrease fear and aggression in pets during veterinary examinations and procedures. Gabapentin’s popularity among veterinary patients is growing. Review the top 5 appropriate and inappropriate uses of gabapentin for dogs and cats in this guide. A survey of clinicians found that gabapentin use in veterinary medicine is similar to use in human medicine; 69% of respondents indicated they prescribe gabapentin on a daily or weekly basis, most commonly for acute and chronic pain (extra-label). 1 Following are the author’s top 5 recommended uses for gabapentin based on mechanism of action and physiology of pain. This study evaluated the effectiveness of gabapentin for reducing stress in hyperthyroid cats at the clinic. Cats (n = 47) were randomly placed into groups given either placebo or gabapentin; owners and veterinary nurses were unaware of treatment group assignments. Feline hyperthyroidism is already tough on cats. Can gabapentin make their frequent clinic visits easier? Find out in this 2-Minute Takeaway from Clinician's Brief. Use of single-dose oral gabapentin to attenuate fear responses in cage-trap confined community cats: a double-blind, placebo-controlled field trial. J Feline Med Surg. 2018;20(6):535-543. Behavior changes may be the first sign of pain in some cats. Explore options for multimodal pain management in senior cats. • Gabapentin may be the best available treatment for facilitating BP measurement in uncooperative or anxious cats or in cases in which an owner requests patient sedation; however, BP measure-ment in calm, cooperative, nonsedated cats is the best approach for obtaining reliable measurements. 2 References 1. In cats, gabapentin is most often used as a pain medication for chronic pain, such as from arthritis. Gabapentin is also recognized as beneficial in reducing the fear responses that a kitty may have to the stress of handling and being examined at the vet. Drugs & Therapeutics Clinical Skills Client Relationships Practice Life Education Gabapentin is commonly used in veterinary medicine for various conditions in dogs and cats, particularly for preclinic sedation, neuropathic pain, breakthrough pain, osteoarthritis, and cancer pain. The Research Trap-neuter-return programs are used extensively for population control among unowned community cats. During trapping and perioperative cage confinement, cats may experience high levels of stress and self-inflicted trauma. Gabapentin, an anticonvulsant used in the treatment of neuropathic pain, has been shown to reduce anxiety in rats and humans. 1,2 Although gabapentin’s Check out the findings of this study that evaluated the effects of gabapentin on blood pressure in healthy cats and cats with stable chronic kidney disease. Gabapentin is widely used in cats to decrease fear and stress and treat some painful conditions (eg, osteoarthritis). Oral administration can be difficult in cats and can lead to treatment failure; less invasive administration methods are thus desirable. This review aimed to clarify gabapentin use and pharmacokinetic aspects to promote conscious use in dogs, cats, and horses. In dogs, gabapentin was useful in the treatment of epilepsy, as well as chronic, neuropathic, and post-operative pain and anxiety.
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