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Though gabapentin has many potential uses, it can cause side effects. Read more about 13 gabapentin side effects here. Gabapentin can cause edema as a side effect, particularly in some individuals. Gabapentin, a medication primarily used to treat nerve pain and seizures, has gained popularity over the years. While it offers relief for many, it’s essential to understand its potential side effects, one of which is edema. This condition involves swelling caused by excess fluid trapped in the body’s tissues Summary: Fluid retention is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Depression. The phase IV clinical study analyzes which people have Fluid retention when taking Gabapentin. Gabapentin isn’t approved for nerve pain from diabetes, but it’s sometimes prescribed off-label. One retrospective study found that people taking it for this reason had a higher risk of heart failure and other cardiovascular problems, possibly due to fluid retention. This was the case with short-term and long-term gabapentin treatment. What Causes Swelling from Gabapentin? Swelling from gabapentin can be attributed to several mechanisms: Fluid Retention One common reason for swelling is fluid retention. Gabapentin can cause changes in kidney function or fluid balance in the body. When the body retains excess fluid, it can lead to noticeable swelling in areas like the legs, ankles, or hands. This difficulty in achieving a high level of exposure to gabapentin could also partly explain a greater propensity of pregabalin to cause non-cardiogenic peripheral edema and acute heart failure. Gabapentin can also cause water retention, which can lead to weight gain. The medication can increase the levels of aldosterone, a hormone that regulates electrolyte and water balance in the body. Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of on- and off-label indications. Gabapentin is dosed at total daily doses ranging from 300 to 3600 mg/d, which is generally Gabapentin Edema: Causes and Management Tips Gabapentin, commonly prescribed for various medical conditions, can sometimes lead to swelling in certain individuals. Understanding the relationship between gabapentin and edema is crucial for patients, as they need to be aware of the potential side effects. Fluid retention in Gabapentin - how severe and when it was recovered? (a real world drug study) Summary: We study how severe was Fluid retention, when it was recovered, drug effectiveness, race, and more among people who take Gabapentin (gabapentin). Related topics , Further information Gabapentin uses and safety info Gabapentin prescribing info & package insert (for Health Professionals) Side effects of Gabapentin (detailed) Similar questions Search for questions Still looking for answers? Try searching for what you seek or . Key takeaways: Gabapentin (Neurontin) is a medication that’s FDA approved to treat seizures and postherpetic neuralgia (nerve pain from shingles). Gabapentin can cause fluid buildup in the legs (edema), which can lead to temporary weight gain. You can also gain weight without fluid buildup, though it’s not common. You may be able to avoid weight gain from gabapentin by adjusting your diet Learn about the side effects of gabapentin, from common to rare, for consumers and healthcare professionals. Gabapentin is an anticonvulsant medication prescribed for a variety of conditions. Learn about its uses, side effects, and what you should know if you've been prescribed this medication. Background Gabapentin and pregabalin are commonly prescribed medications to treat pain in patients with diabetic neuropathy. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. This study aims to Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect Background Gabapentin and pregabalin are commonly prescribed medications to treat pain in patients with diabetic neuropathy. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. This study aims to As gabapentin was the main drug, has been used in both periods, and these side effects have been only observed during the second period so gabapentin could not be the main cause by itself, but the disappearance of side-effects after discontinuing gabapentin intake shows another factor that somehow related to gabapentin has caused the side-effects. Not sure: The mechanism is unclear, but commonly patients will have 2-3 pounds of water retention that will be seen as ankle/foot swelling and will resolve within a few days of stopping the medication. Gabapentin-induced bilateral lower extremity edema in a patient with pervasive developmental disorder and schizoaffective disorder
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