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Gabapentin Hyponatremia Risk & Management Tips Understanding Gabapentin: Uses and Applications Gabapentin Hyponatremia Risk & Management Tips Gabapentin is a drug that doctors often prescribe. It has many uses and plays a big role in treating health issues. It’s mainly an anticonvulsant, but it helps with more than just seizures. Pharmaceutical drugs, e.g., thiazide diuretics, antidepressants and antiepileptic drugs are common causes of both asymptomatic and symptomatic hyponatremia [4]. Since epilepsy is a common disease requiring long-term treatment with antiepileptic drugs, adverse effects such as hyponatremia can be a major problem and deaths have been described [5]. Although gabapentin is generally well tolerated, 1 potential reported adverse effect is peripheral edema. However, due to the extensive number of etiologies of peripheral edema, medication causes may be overlooked on an inpatient psychiatric unit. Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. It’s important for patients on gabapentin to know the signs of hyponatremia. Being able to tell the difference between gabapentin side effects and hyponatremia symptoms is key. Expert opinion: Carbamazepine and oxcarbazepine are the most common AEDs which induce hyponatremia in patients with epilepsy. Recently, other AEDs, such as eslicarbazepine, sodium valproate, lamotrigine, levetiracetam and gabapentin have also been reported to cause hyponatremia. In current clinical practice, psychotropic agents, anticancer chemotherapeutic agents, and thiazide diuretics are the major causes of drug-induced hyponatremia. Among these, vincristine and ifosfamide were associated with sustained plasma AVP levels and are thought to cause SIADH. In acute symptomatic hyponatremia, hypertonic saline solution (3%) is commonly used to acutely increase serum sodium levels and prevent severe neurologic symptoms (eg, seizures). Hypovolemic hyponatremia is treated with adequate fluid resuscitation to decrease the stimulus for ADH secretion. In the case described above, peripheral edema secondary to hyponatremia was first thought to be the potential cause prior to gabapentin identification by the resident pharmacist. In patients experiencing clinically significant hyponatremia, i.e. symptomatic hyponatremia leading to hospitalization, after recent initiation of carbamazepine, oxcarbazepine, phenytoin, valproate or levetiracetam, an alternative treatment could be lamotrigine or gabapentin. Patients on gabapentin should be monitored for symptoms of hyponatremia, such as headache, confusion, nausea, weakness, and in severe cases, seizures or coma. The risk of hyponatremia appears to be higher during the first few weeks of treatment with gabapentin. In current clinical practice, psychotropic agents, anticancer chemotherapeutic agents, and thiazide diuretics are the major causes of drug-induced hyponatremia. Among these, vincristine and ifosfamide were associated with sustained plasma AVP levels and are thought to cause SIADH. In humans, hyponatremia has been associated with dopaminergic agents. 4 An 85-year-old woman with Parkinson disease developed hyponatremia and SIADH after treatment with pramipexole, a dopamine agonist used as anti-Parkinson therapy. 5 Hyponatremia has been noted with the use of levodopa-carbidopa. 4 In another report, hyponatremia also has Various risk factors associated with the development of hyponatremia in patients taking these medications include age, gender, dosage, and combinations with other drugs. ASMs such as carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid have a higher risk of hyponatremia. Hyponatremia (defined as a serum sodium level < 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients. Certain drugs (eg, diuretics, antidepressants, and antiepileptics) have been implicated as established causes of either asymptomatic or symptomatic hyponatremia. However, hyponatremia occasionally may develop in the course of treatment with drugs used in everyday The results of this research point to the fact that gabapentin, an antiepileptic drug with primary application in the treatment of epilepsy and neuropathic pain, can potentially be a cause of hyponatremia, especially among elderly patients and those with existing renal impairment. To evaluate the risk factors and prevalence of hyponatremia among epilepsy patients in relation to use of antiepileptic drugs (AEDs).We retrospectivel Abstract Purpose: Hyponatremia induced by antiepileptic drugs is common, but detailed evidence is lacking. This can be problematic for the treating neurologist confronted with a patient with severe hyponatremia in need of an alternative drug. The objective of this study was to examine the association between individual antiepileptic drugs and hospitalization due to hyponatremia. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of euvolemic hyponatremia, and many medications have been associated with SIADH. Pregabalin is a drug used for the treatment of neuropathic pain, though Summary: Hyponatremia is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Stress and anxiety. The phase IV clinical study analyzes which people have Hyponatremia when taking Gabapentin.
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