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Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat neuropathic pain and also for partial seizures [10][7] of epilepsy. It is a commonly used medication for the treatment of neuropathic pain caused by diabetic neuropathy, postherpetic neuralgia, and central pain. [11] It is moderately effective: about 30–40% of those given The active ingredient in Gabapentin tablets, USP is gabapentin, which has the chemical name 1- (aminomethyl) cyclohexaneacetic acid. The molecular formula of gabapentin is C9H17NO2 and the 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action - The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin | C9H17NO2 | CID 3446 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Gabapentin Chemical Properties, Uses, Production Description Gabapentin is a second- generation antiepileptic drug (AED) known under the proprietary brand name of Neurontin® (Pfizer, New York, NY) in the UK and USA. Generic formulation MHRA/ CHM advice to minimize risk when switching patients with epilepsy between different manufacturers’ products (including generic products): It is usually Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Gabarone package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Gabapentin (CAS 60142-96-3) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices The active ingredient in NEURONTIN capsules, tablets, and oral solution is gabapentin,which has the chemical name 1- (aminomethyl)cyclohexaneacetic acid. The molecular formula of gabapentin is C9H17NO2 and the molecular weight is 171.24. Gabapentin is a white to off-white crystalline solid with a pKa1 of 3.7 and a pKa2 of 10.7. Know about technical details of Gabapentin like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com. Gabapentin readily enters the brain and prevents seizures in a number of animal models of epilepsy. Gabapentin binds with high affinity to the α2δ (alpha-2-delta) subunit of voltage-gated calcium channels and it is proposed that binding to the α2δ subunit may be involved in gabapentin's anti-seizure effects in animals. Gabapentin tablets contain gabapentin USP, a gamma-aminobutyric acid (GABA) analogue, as the active pharmaceutical ingredient. Gabapentin’s chemical name is 1- (aminomethyl)cyclohexaneacetic acid The starting dose is 300 mg three times a day. The recommended maintenance dose of gabapentin capsules is 300 mg to 600 mg three times a day. Dosages up to 2,400 mg/day have been well tolerated in long-term clinical studies. Doses of 3,600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. Administer gabapentin GABAPENTIN (Trade Name: Neurontin®) Introduction: Gabapentin is a prescription medication approved by the United States Food and Drug Administration (FDA) for the treatment of neuropathic pain and epileptic disorders. This drug is currently marketed in capsule, tablet, and oral solution formulations. Gabapentin is a medicine available in a number of countries worldwide. A list of US medications equivalent to Gabapentin is available on the Drugs.com website. Gabapentin is a nonprotein amino acid and a synthetic neurotransmitter that is related to γ-aminobutyric acid1 (GABA). It was first described in 1976 West German patent DE2460891 on cyclic amino acids to Gerhard Satzinger and co-inventors at Goedecke AG (Freiburg). The corresponding US Patent is 4,024,175 (1977). The active ingredient in gabapentin tablets is gabapentin USP, which has the chemical name 1- (aminomethyl) cyclohexaneacetic acid. The molecular formula of gabapentin USP is C9H17NO2 and the 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action - The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are Gabapentin tablet contains gabapentin, a gamma-aminobutyric acid (GABA) analogue, as the active pharmaceutical ingredient. Gabapentin's chemical name is 1- (aminomethyl)cyclohexaneacetic acid ChemSpider record containing structure, synonyms, properties, vendors and database links for Gabapentin, 60142-96-3, UGJMXCAKCUNAIE-UHFFFAOYSA-N Patients taking gabapentin should not drive until they have gained sufficient experience to assess whether gabapentin impairs their ability to drive. Driving performance studies conducted with a prodrug of gabapentin (gabapentin enacarbil tablet, extended-release) indicate that gabapentin may cause significant driving impairment. Gabapentin, USP is a white to off-white powder with a pKa1 of 3.7 and a pKa2 of 10.7. It is freely soluble in water, 0.1 N hydrochloric acid, 0.1 N sodium hydroxide and glacial acetic acid; slightly soluble in methanol, very slightly soluble in ethanol, 2-propanol; insoluble in toluene. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is –1.25.
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