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Chronic pruritus requires careful evaluation for primary dermatologic or systemic causes. In addition to treatment of the underlying cause, when identified, various topical and systemic therapies m Chronic pruritus, one of the main symptoms in dermatology, is often intractable and has a high impact on patient's quality of life. Beyond dermatologic disorders, chronic pruritus is associated with systemic, neurologic as well as psychologic Clinicians should consider prescribing pregabalin and gabapentin for pruritus, potentially replacing conventional treatments while refining dosing strategies and monitoring patient safety based on the reported outcomes. Gabapentin is successfully being used to treat skin conditions associated with pain or pruritus of neuropathic origin. What is gabapentin used for? Gabapentin is proving to be useful in reducing the symptoms of pain and unpleasant sensations caused by the following skin conditions: Pruritus (itch) In patients on haemodialysis (renal itch) Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for relieving chronic pruritus is explored. Treatment with gabapentin and antidepressants should be considered in patients with chronic pruritus unresponsive to conventional treatment. Four drug categories can help to better manage chronic itch Successful treatment of chronic pruritus requires recognizing that its origins might not be as clear-cut as formerly thought, an expert says. Denver - Successful treatment of chronic pruritus requires recognizing that its origins might not be as clear-cut as formerly thought, an expert There is currently no standardized algorithm for the treatment of chronic pruritus (CP), or itch lasting more than 6 weeks, in adults aged ≥ 65 years. The antiepileptic agents gabapentin and pregabalin, however, are gaining popularity in the dermatologic community for their efficacy in treating CP of neuropathic origin. Yet the lack of literature specifically looking at the safety and This systematic review examines the current literature on Gabapentin’s therapeutic effects on all forms of pruritus and compares its efficacy based on etiology, demographics, and dosages. Clinicians should consider prescribing pregabalin and gabapentin for pruritus, potentially replacing conventional treatments while refining dosing strategies and monitoring patient safety based on the reported outcomes. Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for The novel antiepileptic drugs pregabalin and gabapentin demonstrated significant therapeutic value in the treatment of pruritus, with a favorable safety profile. Multiple studies have demonstrated that gabapentin and pregabalin are effective for several forms of pruritus, in particular uremic pruritus and that of neural origin. Gabapentin and pregabalin are promising therapeutic options for pruritus refractory to conventional treatment. genital and neurogenic pruritus; and coolants are mainly effective for neurogenic pruritus.3 Systemic medications, such as antihistamines, are available when topical treatments prove ineffective. Antihistamines block the release of histamine, which stops itching and is most effective in acute histaminergic pruritus. How-ever, antihistamines have limited effectiveness in treat-ing chronic When gabapentin is dosed for the management of chronic pain, the goal is to maintain a steady state in the body to provide adequate pain relief throughout the day; for itch, however, the goal of treatment is to decrease nocturnal pruritus to maximize sleep. Chronic pruritus is due to inflammation in approximately 60% of patients and may be caused by eczema, psoriasis, or seborrheic dermatitis. Chronic pruritus is due to a neuropathic or mixed etiology in approximately 25% of patients. The aim of this study was to evaluate the efficacy and safety of gabapentin and oral antidepressants (Selective Serotonin Reuptake Inhibitors (SSRI’s), Tricyclic Antidepressants (TCA’s) and/or atypical antidepressants) in patients with chronic pruritus in daily clinical practice. For chronic pruritus, initial dosing of 300mg/d and can be increased to 1200mg three times per day. 3 Should be tapered gradually if discontinuing medication to avoid withdrawal symptoms such as seizures. 4 Recently, gabapentin, an antiepileptic agent, has been reported to be an effective antipruritic agent in brachioradial pruritus. 13, 14 It has been suggested that gabapentin may be useful in chronic itching that is unresponsive to other treatments. 15 Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for
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