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Refractory chronic cough causes substantial symptoms and quality-of-life impairment. Similarities between central reflex sensitisation in refractory chronic cough and neuropathic pain suggest that neuromodulators such as gabapentin might be effective for refractory chronic cough. We established the efficacy of gabapentin in patients with refractory chronic cough. However, the clinical trials of gabapentin for chronic refractory cough had some defects: fewer participants, lower research quality and greater bias, compared with other trials of gabapentin for chronic pain and epilepsy. Reviews and ratings for Gabapentin when used in the treatment of cough. 6 reviews submitted with a 6.8 average score. Gabapentin is also used with nerve pain generally so I see some connection there, but if they think your coughing may have a neurogenic component, I suggest you see a laryngologist who specializes in neurogenic coughs as there may be more effective options for you than gabapentin. Objective. This study sought to: (1) quantify response rate and efficacy of amitriptyline, desipramine, and gabapentin in treating sensory neuropathic cough; and (2) describe an efficient treatment protocol. Study Design. This study is a Gabapentin for Cough Reviews What is Gabapentin for Cough? Gabapentin is a medication that has been used to treat various conditions, including nerve pain and anxiety. Recently, some people have turned to gabapentin to help manage a persistent cough. While it’s not a traditional treatment for cough, some individuals have reported finding relief from their symptoms when taking gabapentin Based on the above analysis, we can presume that gabapentin was superior to placebo in the therapy eficacy, improvement of cough-specific quality-of-life, reduction of cough severity and reduction of cough frequency in the treatment of chronic refractory cough, and the adverse effects were comparable to placebo. Gabapentin A randomized, double-blinded, placebo-controlled trial by Ryan et al. evaluated the efficacy of gabapentin for improvement in cough severity and cough-related quality of life. 3 Inclusion and exclusion criteria and dosing are listed in Table I. Twenty-six patients completed the trial in both the placebo and gabapentin arms. Results: The effectiveness of neuromodulating medications such as gabapentin and pregabalin in the treatment of cough has been supported primarily through case series, case reports, prospective reviews and a double blind randomised controlled trial. Gabapentin results in a reduction in cough frequency and cough severity. This systematic review sought to examine evidence for ef-ficacy and safety of gabapentin in the treatment of chronic cough. We examined the data in the current studies regarding this management strategy. Introduction Gabapentin, a neurotransmitter modulator, is thought to treat refractory cough associated with interstitial lung disease by improving cough hypersensitivity. Methods/design This is a single-center, prospective, randomized, double-blind, placebo-controlled trial. The trial will investigate the effect of a 10-week course of oral gabapentin 900 mg/day on refractory cough associated A recent retrospective review of amitriptyline in patients with idiopathic cough noted that it is necessary to titrate or restart the medication for cough control in many patients. 35 Moreover, a retrospective review found a 35% incidence rate of tachyphylaxis in patients treated with neuromodulators. 36 Increasing the neuromodulator dose may Gabapentin is effective in the treatment of chronic refractory cough in both subjective and objective evaluations, and its safety is better than other neuromodulators. Abstract Cough is a common respiratory symptom that is considered to be chronic when it lasts more than eight weeks. When severe, chronic cough may significantly impact an individual's quality of life, and such patients are frequently referred for specialist evaluation. Current international guidelines provide algorithms for the management of chronic cough: in most cases, treatment of the However, the clinical trials of gabapentin for chronic refractory cough had some defects: fewer participants, lower research quality and greater bias, compared with other trials of gabapentin for chronic pain and epilepsy. Despite recent clinical guidelines, the optimal therapeutic strategy for the management of refractory chronic cough is still a challenge. The present systematic review was designed to assess the evidence for efficacy and safety of gabapentin in the Despite recent clinical guidelines, the optimal therapeutic strategy for the management of refractory chronic cough is still a challenge. The present systematic review was designed to assess the evidence for efficacy and safety of gabapentin in the treatment of chronic cough. A systematic search of The most widely used tests include the visual analog scale (VAS) for cough [70, 71] because it is simple and practical, the Leicester Cough Questionnaire (LCQ) [1] and Cough Quality of Life Questionnaire (CQLQ) [72] are all well validated for assessing the impact of cough on health status [73]. The Cough Severity Index (CSI) is a validated a severity index for CC related to the upper airway
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