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Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect This difficulty in achieving a high level of exposure to gabapentin could also partly explain a greater propensity of pregabalin to cause non-cardiogenic peripheral edema and acute heart failure. When asking “Does gabapentin cause leg swelling?” it’s essential to consider how it interacts with individual body chemistry. Swelling can occur for various reasons, including fluid retention or allergic reactions to the medication. I have swelling in my legs caused by lymphedema and have to wear compression socks but mine was not caused by a medication. I also would be concerned if it's been over 5 months since stopping gabapentin and the swelling and pain is still in the hands and feet. Furthermore, experimental data have shown an indirect inhibitory effect of gabapentinoids (ie, gabapentin, pregabalin) on the Cav1.2 channel pore of arterial myocytes, leading to vasodilatory effects and inhibition of the myogenic tone. 96 - 98 These data suggest that gabapentinoid-related peripheral edema 94, 95 may exhibit the same 4 Answers - Posted in: fluid retention, gabapentin, drug - Answer: Yes,. Swelling will go away after using for awhile. My feet were swollen Similarly, the incidence of peripheral edema caused by CCB is dose related and common in the elderly, comparable to reports of gabapentin induced edema. This case illustrates that gabapentin induced leg swelling can confound the clinical picture and it is thus important to recognize this side effect of gabapentin. This is a case of delayed identification of a probable adverse drug reaction to gabapentin (Naranjo score of 5) consisting of painful, 4+ pitting bilateral edema and a clear dose relationship in a patient with pervasive developmental disorder and schizoaffective disorder. Understanding Gabapentin Gabapentin was originally developed to treat epilepsy but has since found its way into the treatment of neuropathic pain and restless leg syndrome. It works by modulating the activity of neurotransmitters in the brain, which helps reduce pain signals. Despite its benefits, gabapentin can lead to various side effects, including dizziness, fatigue, and swelling in Understanding Edema Edema refers to swelling caused by excess fluid accumulation in tissues. It can occur in various parts of the body but is most commonly seen in the legs, ankles, and feet. The causes of edema are numerous, ranging from dietary factors (like excessive salt intake) to medical conditions (such as heart failure or kidney disease). In the context of gabapentin usage This is a case of painful, 4+ pitting bilateral edema with a probable association to gabapentin (Naranjo score 5) and a clear dose relationship in a patient with pervasive developmental disorder and schizoaffective disorder utilizing gabapentin for mood stabilization. Key takeaways: Medications are a common reason for swollen ankles and feet, also called pedal edema. Amlodipine (Norvasc), gabapentin (Neurontin, Horizant, Gralise), and pregabalin (Lyrica) can cause puffy legs and ankles. Birth control pills, certain over-the-counter pain medications, and steroids are a few other culprits. This is a case of delayed identification of a probable adverse drug reaction to gabapentin (Naranjo score of 5) consisting of painful, 4+ pitting bilateral edema and a clear dose relationship in a patient with pervasive developmental disorder and schizoaffective disorder. Edema is an established, but perhaps not widely known, side effect of gabapentinoids. Prior research has demonstrated that gabapentinoid initiation can lead to prescription of loop diuretics, a so-called “prescribing cascade” (NEJM JW Gen Med Dec 1 2021 and J Am Geriatr Soc 2021; 69:2842). In this study, U.S. Veterans Affairs researchers confirmed that cascade and looked for potential risk Does Gabapentin cause swelling of the legs and/or feet? It does to me. It is important to recognize this adverse effect because gabapentin is used in conditions like diabetic neuropathy, which is associated with multiple co-morbidities that can give rise to bilateral leg swelling. Presence of gabapentin induced leg swelling can thus confound the clinical picture. Keywords: Edema, gabapentin, lower extremity As a noticeable point, gabapentin consumption is for treatment of neuralgia, but here neuralgia is one of the gabapentin side-effects. Furthermore, localized edema is a rare side effect that we faced with severe state of it. [3] Leg edema might be occurred in systemic and local types. Gabapentin Edema: Causes and Management Tips Gabapentin, commonly prescribed for various medical conditions, can sometimes lead to swelling in certain individuals. Understanding the relationship between gabapentin and edema is crucial for patients, as they need to be aware of the potential side effects. Kahlon, et al.: Low dose gabapentin induced piting edema in a young male Figure 1: Bilateral pitting edema due to gabapentin genitourinary symptoms. Physical exam was significant for 3+ pitting edema up to his knees bilaterally. Serum sodium, potassium, chloride, and bicarbonate levels were 141 mmol/L, The most common gabapentin (Neurontin) side effects are dizziness and drowsiness. This may affect your ability to drive or perform other activities. Other gabapentin side effects include edema (fluid buildup), weight gain, and eye problems, but these aren’t as common. Rare but serious gabapentin side effects include mood changes in children.
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