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Abstract- Gabapentin (GPN) is a new antiepileptic agent currently in used as add-on therapy in adult patients suffering from partial seizures. The extent of liver damage at different dosage and long term treatment with GPN is not yet clear. Therefore this study was undertaken to find out the possibility of liver damage by this drug. Gabapentin was held. Thereafter, the man's liver function tests improved and remained stable. He discontinued gabapentin. He was advised to follow up outpatient. However, he was lost to follow-up. Based on clinical presentation and investigational findings, he was diagnosed with drug-induced liver injury attributed to gabapentin. Gabapentin (GPN) is a new antiepileptic agent currently in used as add-on therapy in adult patients suffering from partial seizures. The extent of liver damage at different dosage and long term Can gabapentin cause liver enzymes to be elevated? Gabapentin is a unique anticonvulsant used as an adjunctive therapy in managing epilepsy and neuropathic pain syndromes. It is a structural analogue of gamma-aminobutyric acid (GABA) and has been approved for use in the United States in 1993. It is used as an anticonvulsant and neuropathy agent, with over 18 million prescriptions filled Gabapentin is eliminated through the kidneys and, therefore, doesn’t typically cause liver injury. Learn safe dosage recommendations for people with liver disease. Gabapentin is an anticonvulsant medication commonly used to treat epilepsy and neuropathic pain. Rare cases of liver and kidney damage have been reported with Gabapentin use. Individuals with pre-existing liver or kidney conditions may be at a higher risk. Regular monitoring of liver and kidney function is essential while taking Gabapentin. The liver plays a vital role in metabolizing medications, including gabapentin. While most individuals tolerate gabapentin without significant issues, there are rare instances where liver function may be compromised. This article delves deep into the relationship between gabapentin and liver health, exploring mechanisms of action, potential side effects, case studies, and recommendations for Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. There is insufficient data to estimate incidence for these or establish whether gabapentin is the sole cause of elevated liver function tests, notes Pfizer. Gabapentin doesn’t hurt the liver or kidneys in most cases. However, taking a safe gabapentin dose is important to prevent potential side effects. Gabapentin enacarbil is a long acting form of gabapentin that is used for restless leg syndrome and for painful postherpetic neuropathy. Gabapentin enacarbil and gabapentin are associated with a low rate of transient serum enzyme elevations during treatment and with rare instances of clinically apparent liver injury. A full blood count, renal profile, and liver ultrasound scan were also normal. Gabapentin induced cholestasis was thought likely and the drug was stopped. After this, clinical symptoms and liver function tests improved gradually (figure). Antiepileptic drugs (AEDs) are a common cause of drug induced liver injury (DILI). Over the last few decades, several newer AEDs were approved for marketing in the United States, and they are increasingly prescribed for indications other than Therefore, an understanding of liver enzyme levels, often measured via tools such as liver function tests (LFTs), is crucial for patients on gabapentin. The question of whether is gabapentin bad for your liver requires careful evaluation, particularly for individuals with pre-existing hepatic conditions. Question I have a patient with trigeminal neuralgia who was taking 1600 mg of gabapentin and had serious elevations of liver function tests (aspartate transaminase 258 U/L, alanine transaminase Gabapentin can also be used in patients with renal function below 20 mg/dl (although a dosing adjustment is needed). A 2018 clinical review examined gabapentin and other drugs as anti-craving therapy in alcohol use disorder. Gapentin is not metabolized by the liver, and its effects on the liver and kidneys are similar to previous studies. In rare cases, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms). Gabapentin, a gamma-aminobutyric acid (GABA) analogue, has infrequently been reported to cause liver injury; however, the causality in the previous reports is contested. Herein, we report a gabapentin-induced hepatocellular injury in a patient without another identifiable cause for acute liver injury. Gabapentin is a unique anticonvulsant that is used as adjunctive therapy in management of epilepsy and for neuropathic pain syndromes. Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from gabapentin have been reported. Liver and renal functions were impaired by gabapentin; where hepatotoxicity was associated by an imbalance in the redox status. However, magnesium only elevated blood urea nitrogen (BUN). Introduction: Gabapentin is an anti-convulsant that is also used off-label to treat neuropathic pain. It is not metabolized by the liver, and there have been few reports of hepatotoxity associated with it. We present a rare case of gabapentin-induced hepatotoxicity occurring in a young male. Case Description/Methods: A 41-year-old male with an extensive past medical history including type 1
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