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Gabapentin lacks liver metabolism; the mechanism by which it produces liver injury is still unknown; however, there are reports of hepatotoxicity associated with its administration, so its use must be individualized for each patient. Antiepileptic drugs (AEDs) are a common cause of drug induced liver injury (DILI). Over the last few decades, several newer AEDs were approved for marketing in the United States, and they are increasingly prescribed for indications other than Gabapentin-Induced Liver Toxicity Chahal, Japjot MD 1; Arif, Muhammad Osman MD 2; Achufusi, Ted George MD 1 Author Information Gabapentin is not metabolized by the liver. Instead, it is excreted unchanged in your kidneys after circulating in your blood. Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. Liver and renal functions were impaired by gabapentin; where hepatotoxicity was associated by an imbalance in the redox status. However, magnesium only elevated blood urea nitrogen (BUN). Gabapentin enacarbil is a long acting form of gabapentin that is used for restless leg syndrome and for painful postherpetic neuropathy. Gabapentin enacarbil and gabapentin are associated with a low rate of transient serum enzyme elevations during treatment and with rare instances of clinically apparent liver injury. Gabapentin is an uncommon cause of DILI reported to cause a hepatocellular, cholestatic, or mixed picture of liver injury. Given the limitations of prior cases, we feel our report most closely ties gabapentin use to the resultant transaminase elevation. We are reporting a case of drug induced liver injury (DILI) secondary to gabapentin therapy with risk factors for underlying non-alcoholic fatty liver disease (NAFLD). Gabapentin is generally considered safe for the liver, but rare cases of liver damage have been reported. Gabapentin, a medication primarily used to treat nerve pain and seizures, has gained popularity for its effectiveness and relatively mild side effects. Gabapentin is a prescription drug for seizures and nerve pain. It usually doesn't harm the liver or kidneys, but it can cause a rare allergic reaction called DRESS syndrome. Learn more about gabapentin dosing, side effects, and interactions. Gabapentin is an anticonvulsive medication that received approval from the US Food and Drug Administration (FDA) in 1993 and has been available in generic form in the USA since 2004. Gabapentin was originally used as a muscle relaxant and an anti-spasmodic. However, it was later discovered that gabapentin has the potential of an anticonvulsive medication and can be used as an adjunct to more A drug-induced liver injury is one of the most common causes of acute liver failure. While acetaminophen is the most common etiology, other offending medications include amoxicillin-clavulanic acid, amiodarone, isoniazid, and fluoroquinolones to name a few. Gabapentin, a gamma-aminobutyric acid (GAB Gabapentin-Induced Liver ToxicityAm J Ther. 2022 Nov-Dec;29 (6):e751-e752. doi: 10.1097/MJT.0000000000001208. Epub 2020 Jun 5. Learn about the potential effects of Gabapentin on your liver and kidneys. Find out if it is safe to use and how to protect your organs while taking this medication. Gapentin is not metabolized by the liver, and its effects on the liver and kidneys are similar to previous studies. In rare cases, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms). Question I have a patient with trigeminal neuralgia who was taking 1600 mg of gabapentin and had serious elevations of liver function tests (aspartate transaminase 258 U/L, alanine transaminase Gabapentin is eliminated through the kidneys and, therefore, doesn’t typically cause liver injury. Learn safe dosage recommendations for people with liver disease. Consider gabapentin as first line nonopioid therapy, particularly for patients with neuropathic pain. For gabapentin, start 300 mg daily and increase slowly over weeks. Gapentin, a water-soluble amino acid, is eliminated unchanged by the kidneys and there is no appreciable metabolism by the liver. An increase in liver parameters due to GPN caused elevated liver enzyme functions (GOT, GPT, and ALP). Introduction: Gabapentin is an anti-convulsant that is also used off-label to treat neuropathic pain. It is not metabolized by the liver, and there have been few reports of hepatotoxity associated with it. We present a rare case of gabapentin-induced hepatotoxicity occurring in a young male. Case Description/Methods: A 41-year-old male with an extensive past medical history including type 1
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