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SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative THE gabapentinoids pregabalin and gabapentin are both indicated for the treatment of postherpetic neuralgia and as adjuvant therapy for seizure disorders. Pregabalin is additionally approved for the treatment of fibromyalgia and neuropathic pain associated with diabetes mellitus or spinal cord injury. There are now more than 100 clinical trials examining the use of gabapentin peri-operatively Analgesics / therapeutic use* Chronic Pain / prevention & control* Cyclohexanecarboxylic Acids / administration & dosage Cyclohexanecarboxylic Acids / pharmacokinetics Cyclohexanecarboxylic Acids / therapeutic use* Gabapentin Humans Pain, Postoperative / prevention & control* Perioperative Care Pregabalin gamma-Aminobutyric Acid An early study used a single preoperative dose, evaluated patients for only 4 hr postoperatively, and reported substantially (50%) less pain during movement and morphine consumption. An accompanying editorial heralded gabapentin as “a welcome addition to the anesthesiologist’s pharmacopoeia of ‘coanalgesics’”, and interest mushroomed. We evaluated the optimal preemptive dose of gabapentin for postoperative pain relief after single-level lumbar diskectomy and its effect on fentanyl consumption during the initial 24 hours in a randomized, double-blinded, placebo-controlled study in 100 patients with American Society of Anesthesiologists physical status I and II. During the last 15 years, gabapentin has become an established component of postoperative pain treatment. Gabapentin has been employed in a wide range of doses, but little is known about the optimal dose, providing the best balance between benefit Background Gabapentin is an antiepileptic drug used in a variety of chronic pain conditions. Increasing numbers of randomized trials indicate that gabapentin is effective as a postoperative analgesic. This procedure-specific systematic review aims to analyse the 24-hour postoperative effect of gabapentin on acute pain in adults. Methods Medline, The Cochrane Library and Google Scholar were This randomized clinical trial evaluates the effects of perioperative administration of gabapentin on postoperative pain resolution and time to cessation of opioid use. SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative This review evaluated the efficacy and tolerability of peri-operative gabapentin administration to control acute post-operative pain. Peri-operative gabapentin administration was found to be effective in reducing pain scores, opioid requirements and opioid-related adverse effects in the first 24 hours after surgery. Given the significant differences between the studies and the possibility of This systematic review and network meta-analysis evaluates the associations of pain, opioid consumption, and adverse events with different dosages of pregabalin and gabapentin in patients undergoing spine surgery. Consider the following when using gabapentinoids in the perioperative period The evidence supports the use of gabapentinoids in the perioperative period. A typical dose range for perioperative gabapentin is 200-300 mg and 25-50 mg for pregabalin. Given the opioid-sparing effect of gabapentinoids, lower doses of perioperative narcotics may be used. The following keywords including pain management, postoperative pain, total knee arthroplasties, total knee replacement, and gabapentin were used for searching. 1. Inclusion criteria. Studies were considered eligible for inclusion if they met the following criteria: Study design: Randomized controlled trials (RCTs) with placebo report in English. SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ-aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a The optimal dosage for preoperative or perioperative gabapentin depends on the patient and surgical procedure. However, a review of studies from Anesthesiology found that higher doses of gabapentin—like 600, 900, or 1,200 mg—were typically more effective in pain control and reducing opioid consumption than lower doses like 300 mg. Selection criteria: Single oral dose, randomised, double-blind, placebo-controlled trials of gabapentin for relief of established moderate to severe postoperative pain in adults. Data collection and analysis: Studies were assessed for methodological quality and data extracted by two review authors independently. A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 2002; 97: 560–4. Gabapentin Evidence showed that a single dose of gabapentin can lessen postoperative pain and reduce the amount of opioid needed. However, the studies used a range of doses and administered the gabapentin at different times, so the optimal dose and timing of administration remain uncertain. Abstract BACKGROUND: Gabapentin, an anticonvulsant, has recently been suggested as an effective postoperative ‘analgesic’ agent. The objective of the present study was to examine the analgesic effectiveness, opioid-sparing effects and side effects associated with the use of gabapentin in a perioperative setting. METHODS: Following the Quality of Reporting of Meta-analyses recommendations
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