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Lyrica (pregabalin) is a prescription drug that treats nerve pain, fibromyalgia, and other conditions. Learn about generic forms, side effects, dosage, and more. Gabapentin and pregabalin are similar drugs but differ in several distinct ways. The main differences are their indications—specific uses that the Food and Drug Administration (FDA) has approved them to treat—and their dosages. Read on to learn more about which sciatic medications may help to alleviate nerve pain, including medications like Lyrica and gabapentin. Lyrica(Pregabalin) is a prescription medication used to treat nerve pain caused by diabetes, shingles, or spinal cord injury, as well as certain types of seizures. It works by reducing the number of pain signals sent out by damaged nerves. Side effects may include dizziness, drowsiness, and blurred vision. Pregabalin and gabapentin are both FDA approved as an add-on treatment for partial-onset seizures. But pregabalin is approved for adults and children as young as 1 month old, whereas gabapentin is approved for adults and children who are at least 3 years old. Gabapentin and pregabalin are both used to treat partial-onset seizures and nerve pain from shingles (postherpetic neuralgia). Additionally, gabapentin and pregabalin are used off-label to treat a variety of mental health and pain disorders. Both Lyrica and gabapentin are used as anti-epileptic medications and to treat nerve pain. But there are several differences between them. The main differences between Lyrica and gabapentin are: Lyrica is a brand name for pregabalin. Gabapentin is a generic name - brands of gabapentin include Neurontin, Gralise, and Horizant. Gabapentin is indicated as adjunct therapy for partial seizures and postherpetic neuralgia. 4 Pregabalin is indicated for the same uses as gabapentin, plus the management of fibromyalgia and neuropathic pain associated with diabetes, specifically diabetic neuropathy. 5. Lyrica, does have abuse potential. This reinforces the importance of ensuring each patient taking gabapentin has an appropriate indication, dose and frequency to maximize benefit Studies show minimal benefit & more adverse effects when high Lyrica doses are used for diabetic neuropathy (>300 mg/day) and fibromyalgia (>450 mg/day) Pregabalin and gabapentin can both provide relief from pain and be effective ways to manage seizure disorders. However, it’s important to consider the differences between them. Pregabalin is more rapidly absorbed compared to gabapentin, which has a slower absorption rate. Gabapentin is available as a tablet, oral solution, capsule, and extended-release tablet. The half-life of Lyrica is 6.3 hours, and that of Gabapentin is 5-7 hours. Generic name: pregabalin [ pre-GAB-a-lin ] Brand names: Lyrica, Lyrica CR Dosage forms: oral capsule, oral solution, oral extended release tablet Drug class: Gamma-aminobutyric acid analogs Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 23, 2023. Uses Warnings Before taking Dosage Side effects Interactions FAQ What is pregabalin? Pregabalin was originally FDA approved in 2004 An article from the musculoskeletal medicine section of GPnotebook: Switching between gabapentin and pregabalin for neuropathic pain. An overview of possible dose equivalences, switching methods and considerations to make before switching between gabapentinoids in adults with neuropathic pain. Lyrica (pregabalin) and gabapentin are both prescribed for partial onset seizures and nerve pain that occurs after shingles. Doctors also prescribe Lyrica for other uses. Lyrica is a brand-name Standard pregabalin (Lyrica) capsules are available in 8 dosage increments of: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, and 300 mg. Standard gabapentin (Neurontin) capsules are available in 3 dosage increments of: 100 mg, 300 mg, and 400 mg. Gabapentin is approved for treating seizure disorders and nerve damage from herpes zoster (shingles, postherpetic neuralgia). There are many non FDA-approved uses for gabapentin. These include: What are the side effects of Lyrica vs. gabapentin? WARNING. Pregabalin showed superior results compared to gabapentin in the Visual Analog Scale (VAS) at various time intervals up to 12–14 weeks (SMD −0.47, 95% CI −0.74 to −0.19). Gabapentin is typically prescribed at significantly higher doses than pregabalin. For nerve pain, typical doses are 75-150mg of pregabalin twice daily (max 600mg per day). [8] . This is compared with 300-600mg three times per day (max 1800mg per day) for gabapentin. [9]
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