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While gabapentin (Neurontin) is now used in a wide variety of clinical settings — for epilepsy, pain management, restless leg syndrome, anxiety, and sleep disturbance – there is relatively little information regarding its reproductive safety. Most recently, a prospective study from researchers at the Motherisk program reports on the outcomes of 223 pregnancies exposed to gabapentin Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset. Is gabapentin safe during pregnancy? Learn about the potential risks and benefits of taking gabapentin while pregnant, and what you should discuss with your doctor. Gabapentin (Neurontin®) is mainly used to treat epilepsy and nerve pain, and to prevent migraine. What are the benefits of taking gabapentin in pregnancy? Gabapentin prevents epileptic seizures, which can be dangerous to the woman and also lead to pregnancy complications. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. Pregnant women and their physicians should weigh the benefits of treatment with gabapentin with the risks of potential adverse pregnancy outcomes associated with its use. Gabapentin is a gamma-aminobutyric acid (GABA) analog with GABA agonist activity. Gabapentin is an antiepileptic drug that may cause birth defects and harm the fetus. Learn about the risks, benefits, and alternatives of using gabapentin during pregnancy and breastfeeding. Expert insights on gabapentin and pregnancy safety considerations. Learn about risks, benefits, and medical recommendations for managing this medication during pregnancy. Gabapentin is an antiepileptic drug used for various conditions, but its safety in pregnancy is unclear. A large study found no evidence of major malformations, but a slightly higher risk of preterm birth, small for gestational age, and NICU admissions. Gabapentin is not generally recommended in pregnancy as there is not enough information about its safety. It may cause withdrawal symptoms in newborn babies and should only be taken if the benefits outweigh the risks. The combined evidence from this systematic review and animal studies raises concerns about the safety of using gabapentinoids during pregnancy. Careful evaluation of the benefit–risk balance for both mother and fetus/infant is essential when these medications cannot be avoided during pregnancy. This article summarizes the current literature regarding gabapentin use during pregnancy and related prenatal and neonatal exposure outcomes with special consideration for interactions between gabapentin and opioid use. A study from the European Gabapentin Registry included prospective and retrospective data with a total of 51 outcomes and 44 live births of women with epilepsy and other disorders exposed to gabapentin during pregnancy. Due to mixed findings on its safety during pregnancy, gabapentin shouldn’t be taken during pregnancy without first discussing it with your doctor. Gabapentin (Neurontin) is an anti-seizure medication that’s also used for certain types of neuropathic pain. Data on gabapentin use in pregnancy are mixed—some studies suggest it can result in increases in birth defects and other pregnancy Learn about gabapentin use in pregnancy and breastfeeding, including potential risks, benefits, and alternatives. Find out how gabapentin can affect fertility, miscarriage, birth defects, and baby development. Because the risks of taking gabapentin while pregnant in humans are not fully understood, use of gabapentin during pregnancy is determined on a case-by-case basis to determine if the benefits outweigh the risks. Gabapentin is a pregnancy category C, which means risk cannot be ruled out. Does gabapentin cause birth defects? This sheet discusses gabapentin use during pregnancy and breastfeeding, offering guidance on potential risks and safety considerations. Gabapentin and Pregnancy - Gabapentin - GabapentinTo provide information regarding the effects of in utero exposure to gabapentin, physicians are advised to recommend that pregnant patients taking gabapentin enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. How Gabapentin Can Be Addictive Mechanism: Gabapentin affects the brain’s neurotransmitters, particularly by In this large population-based study, we did not find evidence for an association between gabapentin exposure during early pregnancy and major malformations overall, although there was some evidence of a higher risk of cardiac malformations. Maternal use of gabapentin, particularly late in pregnancy In a cohort study of pregnant women included in the US Medicaid Analytic eXtract (MAX) dataset, Elisabetta Patorno and colleagues investigate neonatal and maternal outcomes associated with gabapentin exposure during pregnancy.
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