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Intro Gabapentin has shown to be a significant player in the field of seizure management, extending its influence beyond its initial purpose as a treatment for neuropathic pain. Its introduction to the medical landscape has invited scrutiny and analysis, particularly concerning its efficacy as an adjunctive therapy for various seizure disorders. Understanding gabapentin’s pharmacological Seizures after stroke are an important clinical problem and may result in poor outcomes. The indications of antiepileptic drugs (AEDs) for seizure prophylaxis after stroke remain unclear. This is an updated version of the Cochrane Review previously This systematic review and meta-analysis investigates the association between seizure prophylaxis and risk reduction for early posttraumatic seizures. Gabapentin is 1 of many antiseizure medications available for the treatment of epilepsy in adults; however, there are potential risks associated with its use. Therefore, it is important to determine the place of therapy of gabapentin in the treatment of epilepsy. This page includes the following topics and synonyms: Gabapentin, Neurontin, Horizant, Gralise, Gabapentinoid. This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of gabapentin monotherapy for people with epileptic partial seizures with and without secondary generalisation. Gabapentin has minimal interaction with drugs metabolized by the liver and is usually well tolerated when used with other drugs (5). Therefore, gabapentin may be an alternative to valproate as a prophylaxis for clozapine-induced seizures in patients intolerant of treatment with valproate in combination with clozapine. Comprehensive information on antiseizure medications, including mechanisms of action, pharmacology, and adverse effects. Antipsychotic Agents / therapeutic use Clozapine / adverse effects* Clozapine / therapeutic use Cyclohexanecarboxylic Acids* Drug Administration Schedule Epilepsy / chemically induced* Epilepsy / prevention & control* Gabapentin Humans Male Schizophrenia / drug therapy Secondary Prevention Treatment Outcome gamma-Aminobutyric Acid* Gabapentin for Seizures: Drugs [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2024 Oct. Table 9, Summary of Recommendations in Included Guidelines. Many patients with primary brain tumours or brain metastases may never have a seizure and so the risks of medication for seizure prophylaxis will outweigh any benefits. These guidelines help to address in which patient’s seizure prophylaxis should be commenced and which anticonvulsants may be most appropriate. Alcohol-related seizures are defined as “adult onset sei-zures that occur in the setting of chronic alcohol dependence.”40 Yet alcohol withdrawal per se is the cause of seizures only in a subgroup of these patients.40 In fact, approx-imately 50% of the seizures experienced by alcoholic subjects are a result of concurrent organic causes For example, clozapine-induced seizures have been reported from oral clozapine, but these seizures have been successfully treated with anti-epileptic medications such as gabapentin, carbamazepine Gabapentin is a relatively new antiepileptic drug with a benign side effect profile and a lack of significant pharmacokinetic interactions (2)). We report the case of an adolescent who experienced seizures with clozapine and was successfully treated with clozapine several years later with the use of gabapentin as a prophylaxis. Here, we present the guidelines for seizure prophylaxis following TBI. The main questions we aimed to address were the fol-lowing: (1) Should prophylactic ASM versus no ASM be used in patients hospitalized with TBI? Gabapentin Gabapentin is a medication indicated for use in to treat different seizure presentations, peripheral neuropathic pain and migraine prophylaxis. Other uses include bipolar disorder and post-herpetic neuralgia, though these are off-label uses. Abstract Background: Gabapentin is considered a safe and well-tolerated antipileptic drug (AED) with a favorable pharmacokinetic profile and a broad therapeutic index. However, recent studies have used higher doses and faster titration schedules than those used in the pivotal trials that established the efficacy of gabapentin in the treatment of partial seizures. ASMs prophylaxis are recommended for patients with a seizure history, which means secondary prophylaxis, and specific high-risk groups, but not recommended for primary prophylaxis routinely for those without a history of seizure. Therapy of the acute SE episode is directed toward stopping seizures, while prophylaxis of long-term consequences has received less attention. Most experiments focused on abnormalities post-SE have used models of generalized seizures and assessed effects in the hippocampal-limbic system. Such abnormalities presumably result in long term sequelae in survivors, including disordered cognition, development of epilepsy de novo or worsening of existing seizures. Therapy of the acute SE episode is directed toward stopping seizures, while prophylaxis of long-term consequences has received less attention.
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