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Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain. Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024 Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. A recent study by Case Western University reveals a concerning link between gabapentin, a common drug for nerve pain and epilepsy, and an increased risk of dementia and mild cognitive impairment I’ve never experienced any known side effects from it. I have read that long-term use of gabapentin can increase the chances of dementia. Key Takeaways: Gabapentin use has been associated with memory loss and cognitive decline. Studies suggest that the risk of dementia may be higher in patients treated with gabapentin. It is important for patients and healthcare providers to be aware of the potential cognitive side effects of gabapentin. A retrospective cohort study was conducted using the National Alzheimer’s Coordinating Center Uniform Data Set (2005-March 2023). Participants with cognitive impairment at the visit of gabapentin initiation (i.e., index visit) were included. Using the incidence density sampling method, up to 9 non-users were randomly selected for each initiator. Thus, this study aimed to examine the association of gabapentin initiation with cognitive and motor function decline in older adult participants with cognitive impairment. Methods: A retrospective cohort study was conducted using the National Alzheimer's Coordinating Center Uniform Data Set (2005-March 2023). Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine. What’s more, the risk was more than doubled in people normally considered too young to suffer from brain aging, those 18 to 64, results show. Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)--29% and 85 To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia Summary: Dementia is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Parkinson's disease. The phase IV clinical study analyzes which people have Dementia when taking Gabapentin. It is created by eHealthMe based on reports of 313,421 people who have side New data suggest an association between gabapentin for chronic back pain and increased risk of cognitive impairment, although experts urge caution in drawing any firm conclusions. Thanks to its low addictive potential, gabapentin is usually seen as a safer option to opioids, however, the new findings raise concerns on its potential side effects on brain health. Key Takeaway While gabapentin can be safe and effective for many elderly patients, it requires careful consideration of individual health factors, potential side effects, and drug interactions to ensure its appropriate use in this population. It may be reasonable to start older adults on a low dose of gabapentin, which can be effective to treat pain while exposing patients to a lower risk of adverse mental status side effects of gabapentin (dizziness, drowsiness and confusion) [7]. Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and However, as with many medications, health concerns arise—especially concerning its potential link to neurodegenerative diseases like Alzheimer’s. In this article, we will explore the effects of Gabapentin on brain health, its side effects, and the latest research findings regarding its relationship with Alzheimer’s disease. The long-term effects of gabapentin on dementia risk, particularly among patients with chronic pain, remain inadequately explored. Although previous studies have established a link between chronic pain and elevated risk of cognitive dysfunction, including dementia (Kao et al., 2021; Chen et al., 2023; Cao et al., 2019), the literature is sparse The anti-seizure drug gabapentin is used to treat epilepsy, nerve pain after shingles and restless legs syndrome by affecting chemical messengers in the brain and nerves. Common side effects In clinical practice, the duration of gabapentin or pregabalin therapy mainly depends on the clinical symptoms and adverse effects of the treatment. After a literature review, we were unsure of the duration the drugs would require to cause the side effects of cognitive impairment or dementia.
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