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Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and If you’ve been taking gabapentin and suffer from side effects, you might be looking for safer medications. In this article, I’ll talk about gabapentin alternatives, precautions to take before switching, and side effects to look out for. To examine this further, researchers analyzed records for more than 26,400 people who had been prescribed gabapentin for chronic low back pain, and compared them to a similar number of other back A range of alternatives to gabapentin that may be effective are available. These include prescription medication options, over-the-counter substitutes, and natural remedies. Pregabalin is Gabapentin alternatives for epilepsy, nerve pain, and anxiety. Other drugs for nerve pain include topiramate, baclofen, tricyclic antidepressants such as amitriptyline and Dosulepin, and serotonin-norepinephrine reuptake inhibitors such as duloxetine. For those who prefer medication but want something different from Gabapentin, several prescription options exist: Pregabalin (Lyrica): Similar in structure and function to Gabapentin but often considered more effective for certain types of nerve pain. Amitriptyline: An antidepressant that is also effective in treating chronic pain conditions. Compare Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Several alternatives to gabapentin exist for treating neuropathic pain. Pregabalin (Lyrica) is closely related to gabapentin and often effective at doses of 150-600mg daily, divided into two or three doses. Gabapentin Alternatives The mechanism of action of gabapentin alternatives is usually similar to that of prescription drugs. Pregabalin The prescription-only drug pregabalin (Lyrica) is closely related to gabapentin. Children under the age of 65 should not take this medication. It is only appropriate for adults (under age 65). Epilepsy, nerve pain, and anxiety disorders can be treated with it Key takeaways: Pregabalin (Lyrica) and gabapentin (Neurontin) are medications that treat certain types of seizures and nerve pain. Pregabalin has more FDA approved uses. Both are frequently used off-label for a wide range of health conditions. When comparing pregabalin versus gabapentin, they work in similar ways but pregabalin is absorbed more quickly and fully. Common side effects of both Both gabapentin and Lyrica are available as generic medications. Gabapentin is an older drug, with multiple generics available at a much lower cost than Lyrica. The generic version of Lyrica, pregabalin, was recently made available in July 2019. Similar to other anticonvulsant medicines, Neurontin may increase the risk of depression and suicidal thoughts, particularly in young adults under the age of 24. Cymbalta, Elavil, Klonopin, Lipoderm, and Lyrica are some gabapentin alternatives. Get the full prescription list here, including natural alternatives. Your doctor may prescribe you an antidepressant instead of a GABA analogue, like gabapentin, to treat pain, based on your individual health profile. According to Harvard Health, these medications include: Some people, alongside the guidance of their doctor, may decide to seek treatment without medication. Drugs like gabapentin and pregabalin, Neurontin, and Lyrica bind these receptors at the alpha-2-delta subunit of the Cav2.2 channel, reducing pain signal transmission. Pregabalin Pregabalin is similar to gabapentin in that it blocks the release of neurotransmitters. Two potential benefits of pregabalin are improved bioavailability (the amount of the drug that enters the bloodstream) and a longer half-life. What this translates to is that pregabalin only needs to be given twice a day. There are several alternatives to Gabapentin, including pregabalin, duloxetine, and various natural remedies. Gabapentin is a medication primarily used to treat nerve pain and seizures. To examine this further, researchers analyzed records for more than 26,400 people who had been prescribed gabapentin for chronic low back pain, and compared them to a similar number of other back pain patients who hadn’t gotten the drug. Compare Lyrica head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds.
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