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Women receiving tamoxifen for the treatment or prevention of breast cancer should be aware of possible drug-drug interactions between tamoxifen and specific antidepressant medications. Antidepressants are used widely to treat depression and anxiety disorders in midlife women. The selective serotonin-reuptake inhibitors are regarded as the most promising non-hormonal treatment for hot flashes in women with breast cancer, but a study by Stearns and colleagues has raised concern about the possible interaction between these agents and tamoxifen, a selective oestrogen-receptor modulator, because selective serotonin Tamoxifen Interactions There are 460 drugs known to interact with tamoxifen, along with 5 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 134 are major, 311 are moderate, and 15 are minor. Tamofen Interactions There are 461 drugs known to interact with Tamofen (tamoxifen), along with 5 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 134 are major, 312 are moderate, and 15 are minor. The authors conclude that gabapentin at dosages of at least 900 mg is effective in reducing symptoms of hot flashes in women with breast cancer. These results correlate with studies in The addition of venlafaxine and citalopram but not gabapentin during tamoxifen treatment decreases plasma Z-endoxifen concentrations. SSRIs/SNRIs affecting tamoxifen biotransformation pathways, but with less potent CYPi potential, should be used cautiously in tamoxifen-treated patients and non-CYP inhibiting medications considered when possible. Abstract Objective: Tamoxifen, a medication used in the treatment of breast cancer, often induces menopausal symptoms. Certain medications and natural supplements taken or prescribed to alleviate tamoxifen-induced hot flashes and depressive states in women with breast cancer interact with tamoxifen. This paper reviews potentially problematic interactions and offers treatment recommendations. Tamoxifen, a medication used in the treatment of breast cancer, often induces menopausal symptoms. Certain medications and natural supplements taken or prescribed to alleviate tamoxifen-induced hot flashes and depressive states in women with breast cancer interact with tamoxifen. This paper reviews potentially problematic interactions and offers treatment recommendations. Drug Interactions between gabapentin and Tamoxen This report displays the potential drug interactions for the following 2 drugs: gabapentin Tamoxen (tamoxifen) Edit list (add/remove drugs) Consumer Professional Interactions between your drugs No interactions were found between gabapentin and Tamoxen. Find patient medical information for Tamoxifen on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings However, since SSRIs and SNRIs have been demonstrated to decrease hot flashes in otherwise healthy postmenopausal women who are not taking tamoxifen, and since citalopram, venlafaxine and gabapentin are as effective in reducing hot flashes as strong CYP2D6 inhibitors in women taking tamoxifen, the mechanism by which these antidepressants reduce Gabapentin is an anti-epileptic medication, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. It is used in adults to treat nerve pain caused by her.. Read More Tamoxifen and Gabapentin have been mentioned in 72 conversations on the web Pandya and his group are also planning an open-label comparison between gabapentin and oral clonidine. In a previous double-blind, controlled trial, they found oral clonidine to be effective against tamoxifen-related hot flushes. Side-effects were “not all that bad”, Pandya adds, especially compared with side-effects of the clonidine patch. Tamoxifen, which is prescribed for the treatment of breast cancer, can interact with some commonly used drugs and over-the-counter nutritional supplements. You may be taking tamoxifen for at least five to 10 years, so it's important to be aware of its potential interactions with medications you are He added that there is concern in some quarters about an interaction between SSRIs and tamoxifen because the former inhibit the enzymes important to converting tamoxifen to its active metabolites. “But gabapentin definitely should be added to the list of nonhormonal agents used to treat the hot flashes of breast cancer,” he said. Women receiving tamoxifen for the treatment or prevention of breast cancer should be aware of possible drug-drug interactions with specific antidepressant medications (e.g., SSRI). These antidepressants are used widely to treat depression and anxiety disorders. In addition, multiple studies have shown that these antidepressants are an effective non-hormonal treatment for hot flashes; over 25% Tamoxen Interactions There are 462 drugs known to interact with Tamoxen (tamoxifen), along with 5 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 135 are major, 312 are moderate, and 15 are minor. A phase IV clinical study of FDA data: drug interactions are found among 314 people who take Gabapentin (gabapentin) and Tamoxifen citrate (tamoxifen citrate). In this pilot study, 22 women with breast cancer on tamoxifen therapy with at least two hot flashes a day took oral gabapentin at 300 mg three times a day for 4 weeks. The 16 women who completed the study had a mean decrease in hot flash duration of 73.6% (P = 0.027), frequency of 44.2% (P < 0.001), and severity of 52.6% (P < 0.001), with a complete response in 8/16 women. Side effects Side effects reported by four women who did not complete 4 weeks of the study were nausea (1/4), rash (1/4) and excessive sleepiness (3/4). Two additional patients did not provide complete data. Gabapentin is a promising new agent in the treatment of tamoxifen induced hot flashes, and should be studied further.
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