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Discover how this protocol uses gabapentin, melatonin, and acepromazine to decrease fear and aggression in pets during veterinary examinations and procedures. Chill Protocol The Chill Protocol is a combination of orally administered medications to facilitate procedural management of animals that exhibit signs of anxi-ety and/or aggression. The protocol consists of at-home administration of gabapentin, melatonin, and oral transmucosal (OTM) acepromazine (10 mg/mL injectable formulation) prior to a medical appointment (see Treatment at a Glance: Chill When it comes to calming your dog during stressful situations, whether for vet visits, grooming sessions, or travel, there are three major medications often recommended by veterinarians: Acepromazine, Trazodone, and Gabapentin. But which one is the best for your dog’s specific needs? Key Takeaways 🗝️ Acepromazine is a strong sedative that works well for extreme anxiety but can impair trazodone, gabapentin and acepromazine I recently took my 10 month old dog to the vet for a nail trim, and an anal gland expression. He wanted nothing to do with it so we ended the appointment and they sent us home with trazodone. We rescheduled so we could try again with the trazodone. ded medications. Additionally, each go-home medication should be discussed with the owner in terms of patient risk(s) and what t expect at home. The therapies introduced in this brief article, acepromazine, gabapentin, trazodone, and melatonin, are meant to supplement low-stress handling (e.g., bringing overly aggressive dogs directly Anxiolytic, Sedation, and Premedication Drug Combinations Use this chart to determine which drug-class combinations may benefit your individual patients based on their health, demeanor, and the reason they require medication, including simply to calm their nerves. When your dog is facing anxiety, pain, or surgery recovery, medications like trazodone and gabapentin are often prescribed to help manage symptoms and keep your pet comfortable. These drugs can be powerful tools in your vet’s arsenal, but understanding how they work, what they’re used for, and potential side effects is key to making informed decisions for your pet’s The primary side effect of short term administration of gabapentin is somnolence – which is why it comes in handy for us as an oral pre-visit sedative! Gabapentin works particularly well in cats to decrease reactivity to transport and veterinary visits. (1, 2) The typical starting dose is about 20 mg/kg but this can be increased dramatically. Can I give my dog trazodone and gabapentin at the same time? Since Trazodone has a mild sedating effect, Gabapentin will provide additional sedating effects along with pain relief. Chill Protocol Gabapentin 20-25 mg/kg PM prior Gabapentin 20-25 mg/kg, melatonin 3-5 mg/dog, OTM acepromazine 0.05 mg/kg PO 90-120 minutes prior Literature: Costa et al. 2023 evaluated the protocol. References 023). Gabapentin, melatonin, and acepromazine combination pri r to hospital visits decreased stress scores in aggressiv Gabapentin and trazodone are used to treat anxiety in dogs. The standard dose of gabapentin and trazodone for dogs is gabapentin at 10 mg/kg and trazodone at 5 mg/kg. -or- Gabapentin (20+ mg/kg, PO, 2 – 3 hours before travel/arrival) +/- injectable Acepromazine (0.025 – 0.05 mg/kg, given via oral transmucosal route, 30 min prior to travel) tal visit then add the Acepromazine oral transmucosal 3 This is just not as effective in dogs as it is in cats. I use oral gabapentin in small breed dogs. Unfortunately, I would not recommend acepromazine in a 15 year old dog; sometimes, it can cause a severe drop in blood pressure. Perhaps we can increase the dose of gabapentin or trazodone instead? What doses of those medications is he on? We can usually go quite high on the gaba to get a more sedating effect. • Trazodone 4-12 mg/kg PO and Gabapentin 20 mg/kg PO For small dogs liquid preparations can facilitate administration of the medication and accuracy of dosing. ional arousal is a significant factor the use of noradrenergic acting medication such as Sileo® (according to manufacturers publis ent alone. For particularly challenged patients and Gabapentin and trazodone are two medications commonly used in veterinary medicine to treat a variety of conditions in dogs. When used together, these medications can provide effective relief for dogs suffering from anxiety, pain, or other medical issues. Abstract This review focuses on pre-appointment medications used to decrease fear and anxiety in dogs and cats related to veterinary visits. A review of the literature revealed data on 4 medications from 4 medication classes that have been used to ameliorate acute situational fear and anxiety in dogs and cats: gabapentin, trazodone, oral transmucosal dexmedetomidine, and alprazolam. The Common oral premed cocktails for dogs: Trazodone + clonidine Trazodone + gabapentin Trazodone + acepromazine Trazodone + clonidine + gabapentin Trazodone + acepromazine + gabapentin *Lorazepam can be added to any of the above combinations in non-fractious patients. All are safe premeds for injectable sedation in healthy dogs. Trazodone is an anti-anxiety medication, while acepromazine is a sedative/tranquilizer. When they are given together, dogs often become very sedated (tired) and ataxic (wobbly while walking). Trazodone and gabapentin are both medications commonly used in veterinary medicine to manage anxiety and behavioral issues in dogs and cats. Gabapentin, traditionally used as an anticonvulsant and for neuropathic pain, has also been found to be effective in treating social anxiety and panic disorder in humans. Trazodone and gabapentin have wide safety margins and are effective for calming most dogs and cats prior to their veterinary clinic visit. Although either species could have either drug, trazodone seems to be most effective for dogs and gabapentin seems to be most effective for cats.
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