Abstract Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. Most women receiving systemic therapy for breast cancer experience hot flashes. We undertook a randomised, double-blind, placebo-controlled, multi-institutional trial to assess the efficacy of gabapentin in controlling hot flashes in women with Other agents that have been used to alleviate hot flashes include belladonna/ergotamine tartrate/phenobarbital combination, dong quai, evening primrose oil, gabapentin, ginseng, mirtazapine The use of gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women by 20% to 30%, but the high level of heterogeneity across the studies precluded the provision of a reliable summary effect. Gabapentin (Neurontin) has emerged as an effective non-hormonal treatment for menopausal hot flashes, with doses ranging from 600 to 2400 mg/day showing significant reduction in both frequency and severity. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Gabapentin is primarily known as an anticonvulsant medication used to treat epilepsy and neuropathic pain. However, its off-label use for managing hot flashes has gained attention in recent years. Understanding the efficacy of gabapentin for this purpose involves examining clinical studies, patient experiences, and the underlying mechanisms of how the drug works. Understanding Hot Flashes Hot Discover if gabapentin can help alleviate hot flashes. Learn about its effectiveness, potential benefits, and side effects for menopausal symptom relief. An investigational nonhormonal drug, extended-release gabapentin, effectively improved sleep and reduced hot flashes in menopausal women. Gabapentin 600-2400 mg/day in divided doses may be a viable option for treating hot flashes in menopausal women who do not want to use hormone replacement therapy. Gabapentin is an anticonvulsant drug that has shown promise in reducing hot flash frequency and severity. Clinical studies suggest it is an effective treatment for menopausal-related vasomotor symptoms. While it offers alternatives to hormone replacement therapy (HRT), gabapentin is not without side effects that need consideration. Buy SDC Metrics Abstract Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. Methods: Gabapentin (Neurontin, Gralise, others). This antiseizure medicine helps ease hot flashes. Side effects can include being drowsy, dizzy or tired and swelling in the arms and legs, called edema. Pregabalin (Lyrica). This is another anti-seizure medicine that can help ease hot flashes. Although hormone therapy remains the gold standard for menopausal hot flashes, other remedies should also be offered. Abstract Hot flashes occur frequently in menopausal women and in women with breast cancer, diminishing their quality of life. A report from the Women's Health Initiative published in 2002 raised concerns about the long-term safety of estrogen therapy. As a result, nonhormonal alternatives have emerged as preferred treatments. Gabapentin is an anticonvulsant that the United States Food and Drug I’d already been prescribing gabapentin for some time for chronic pain when research using this drug for hot flashes hit the presses, so I was able to quickly add it to my hot flash armamentarium. I see quite a lot of women in menopause who can’t take hormones for a variety of reasons, so between my pain and my menopause practices I have a lot of experience prescribing gabapentin. The North American Menopause society and the American College of Obstetricians and Gynecologists recommend the use of gabapentin as an option for managing hot flashes in women who are unwilling to take estrogen-containing supplements. Fortunately, a new treatment option may be able to treat hot flashes without the risk. Gabapentin, an anticonvulsant, may be effective for the treatment of hot flashes. Often sold as Neurontin, gabapentin is approved by the Food and Drug Administration (FDA) for the treatment of epilepsy. Gabapentin is effective in reducing the frequency and severity of hot flashes, particularly for those experiencing menopausal symptoms. Originally used for epilepsy and neuropathic pain, it has been found to offer significant relief from hot flashes. Key Benefits: Reduces hot flash frequency Lessens hot flash intensity
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