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Gabapentin is indicated for: Neuropathic pain caused by postherpetic neuralgia Adjunctive therapy in the treatment of partial seizures with or without secondary generalization Neuropathic pain caused by diabetic peripheral neuropathy and spinal cord injury Restless leg syndrome (gabapentin enacarbil) Gabapentin is frequently used off-label for: Gabapentin may also be used to treat other nerve pain conditions (such as diabetic neuropathy, peripheral neuropathy, trigeminal neuralgia) and restless legs syndrome. Gabapentin is an anti-epileptic drug, also called an anticonvulsant. It is used to treat some types of seizures and nerve pain caused by shingles. Gabapentin is an anticonvulsant drug that has been used for a number of off-label indications, including neuropathic pain. It is thought to act by binding to calcium channels and modulating calcium influx, or by blocking new synapse formation. Neuropathic pain tends to be chronic, is complex, and can be difficult to treat effectively. Treatment often involves pharmacologic and physical Abstract Background Gabapentin is commonly used to treat neuropathic pain (pain due to nerve damage). This review updates a review published in 2014, and previous reviews published in 2011, 2005 and 2000. Objectives To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain in adults. Search methods For this update we searched CENTRAL), MEDLINE, and Embase Oral gabapentin dosed at 1,200 mg or more daily demonstrated a 50% reduction in pain intensity, with a number needed to treat (NNT) of eight for postherpetic neuralgia and an NNT of six for For short-term treatment of painful diabetic neuropathy and postherpetic neuralgia, gabapentin may be as effective as tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, or pregabalin (based on indirect evidence). Confusion was also more frequent in the gabapentin group (7 [8%] vs 1 [1.2%]; P = .06). Conclusion.— Gabapentin monotherapy appears to be efficacious for the treatment of pain and sleep interference associated with diabetic peripheral neuropathy and exhibits positive effects on mood and quality of life. Gabapentin is an anticonvulsant (antiseizure) medication approved by the FDA to treat several conditions. Doctors sometimes prescribe gabapentin "off-label" to treat other conditions as well. A 2022 report stated that gabapentin was among the 10 most commonly prescribed medications in the U.S. What is gabapentin and what is it used for? Gabapentin is used to control seizures, to treat nerve Sometimes other terms are used, including cryptogenic neuropathy or chronic polyneuropathy of undetermined cause. For some people, neuropathy is due to diabetes, alcohol abuse, medications, or other conditions. Gabapentin was effective in the treatment of painful diabetic neuropathy, postherpetic neuralgia, and other neuropathic pain syndromes. It relieved symptoms of allodynia, burning pain, shooting pain, and hyperesthesia. Adverse effects were typically mild to moderate and usually subsided within approximately 10 days from the initiation of treatment. In the 2016 report, most of the available randomized control trial (RCT) data pertained to diabetic peripheral neuropathy (DPN) and post-herpetic neuralgia (PHN), it was concluded that for DPN there was greater reduction in neuropathic pain and increased risk of adverse events associated with gabapentin compared with placebo. Gabapentin can help relieve nerve pain in some people with postherpetic neuralgia (nerve pain after shingles) and peripheral diabetic neuropathy (nerve pain in the feet in people with diabetes). What Is Gabapentin and How Does It Work? Gabapentin is a medication primarily used to treat nerve pain by calming down the overactive nerves responsible for transmitting pain signals. It’s often prescribed for conditions like peripheral neuropathy, post-herpetic neuralgia (pain after shingles), and other nerve-related disorders. Gabapentin was developed to treat epilepsy, but it is now used to treat various forms of chronic pain. On 17 March 2014 we performed searches to look for clinical trials where gabapentin was used to treat neuropathic pain or fibromyalgia. We found that 5633 participants had been involved in 37 studies of reasonable quality. Painful diabetic peripheral neuropathy occurs in approximately 25% of patients with diabetes mellitus who are treated in the office setting and significantly affects quality of life. It typically Peripheral neuropathy is difficult to treat successfully; tricyclic antidepressants are effective at reducing pain, but intolerable side effects often limit their use. Gabapentin is approved to treat seizures and postherpetic neuralgia, a type of nerve pain following shingles. It is thought to work by changing how nerves send messages to your brain. It is also used off-label to treat other neuropathic pain conditions. Painful diabetic peripheral neuropathy occurs in approximately 25% of patients with diabetes mellitus who are treated in the office setting and significantly affects quality of life. It typically Pain relievers. Medicines available without a prescription, such as nonsteroidal anti-inflammatory drugs, can improve mild symptoms. Anti-seizure medicines. Medicines such as gabapentin (Gralise, Neurontin, Horizant) and pregabalin (Lyrica), developed to treat epilepsy, often improve nerve pain. Side effects can include drowsiness and dizziness. Topical treatments. Lidocaine cream that is
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