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Frequent use of common pain drug linked to increase in dementia and cognitive decline, study suggests. Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and Gabapentin for back pain may increase dementia risk by 29% after six prescriptions, study finds. Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. The evidence of gabapentin and dementia is mixed, with two studies looking at hundreds of thousands of people and coming to completely different conclusions. Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., Abstract Study objective To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia in an aging population and the potential cognitive impacts of chronic pain management. A recent study by Case Western University reveals a concerning link between gabapentin, a common drug for nerve pain and epilepsy, and an increased risk of dementia and mild cognitive impairment Background Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. Howev Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine. What’s more, the risk was more than doubled in people normally considered too young to suffer from brain aging, those 18 to 64, results show. New data suggest an association between gabapentin for chronic back pain and increased risk of cognitive impairment, although experts urge caution in drawing any firm conclusions. In clinical practice, the duration of gabapentin or pregabalin therapy mainly depends on the clinical symptoms and adverse effects of the treatment. After a literature review, we were unsure of the duration the drugs would require to cause the side effects of cognitive impairment or dementia. Conclusions Gabapentin prescription in adults with chronic low back pain is associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults. Physicians should monitor cognitive outcomes in patients prescribed gabapentin. Research shows that patients with six or more prescriptions for gabapentin, commonly used to treat lower back pain, were 29% more likely to be diagnosed with dementia and 85% more likely to be diagnosed with mild cognitive impairment within 10 years of their initial pain diagnosis. Gabapentin, which is used to treat seizures, nerve pain and restless leg syndrome might be linked with increased risk of dementia, a new study says. Gabapentin (Neurontin) prescriptions for chronic low back pain were linked with an increased risk of dementia and cognitive impairment, especially in younger people, an analysis of U.S. healthcare Gabapentin prescription in adults with chronic low back pain is associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults. Physicians should monitor cognitive outcomes in patients prescribed gabapentin. Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain. Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024 A new study warns that gabapentin can significantly increase the risk of dementia and mild cognitive impairment in people taking it for chronic low back pain. ryanking999 – stock.adobe.com Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine.
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