neurontin hyponatremia neurontin during pregnancy

The study aimed to analyze the incidence and risk factors of hyponatremia due to gabapentin in patients undergoing gabapentin therapy for various neurological and pain disorders. Hyponatremia is an important electrolyte abnormality with the potential for significant morbidity and mortality. Common causes include medications and the syndrome of inappropriate antidiuretic Hyponatremia is an adverse effect of some antiepileptic drugs (AEDs) and has been especially reported under oxcarbazepine (OXC) and carbamazepine (CBZ) (Dong et al., 2005; Lu and Wang, 2017). Rarely, other AEDs such as valproic acid (VPA), lamotrigine (LTG) or levetiracetam (LEV) have been shown to be linked with hyponatremia (Branten et al., 1998; Mancano, 2016; Nasrallah and Silver, 2005 Abstract Purpose: Hyponatremia induced by antiepileptic drugs is common, but detailed evidence is lacking. This can be problematic for the treating neurologist confronted with a patient with severe hyponatremia in need of an alternative drug. The objective of this study was to examine the association between individual antiepileptic drugs and hospitalization due to hyponatremia. Drug-induced hyponatremia caused by renal water retention is mainly due to syndrome of inappropriate antidiuresis (SIAD). SIAD can be grouped into syndrome of inappropriate antidiuretic hormone secretion (SIADH) and nephrogenic syndrome of inappropriate antidiuresis (NSIAD). In brief, nephrogenic antidiuresis, or NSIAD, is the major mechanism for drug-induced hyponatremia. The associations between pharmacogenetic variants and drug-induced hyponatremia is an area of ongoing research. Gabapentin is associated with a lower risk of hyponatremia compared to other antiepileptic drugs, with an adjusted OR of 1.61 (95% CI, 1.08-2.38) for newly i The incidence, clinical symptoms, onset times of AEDs-induced hyponatremia are discussed in detail, as are the risk factors associated with AEDs-induced hyponatremia and mechanisms underlying its development. We also briefly describe strategies for treating AED-induced hyponatremia. Learn how Neurontin is used to treat hyponatremia, a condition of low sodium levels in the blood, and its potential effects on patients. In the excellent review of drug-induced hyponatremia, Liamis et al1 gave clinical information about the incidence of hyponatremia associated with specific drug treatment and discussed the underlying pathophysiological mechanisms. Summary: Hyponatremia is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Stress and anxiety. The phase IV clinical study analyzes which people have Hyponatremia when taking Gabapentin. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of euvolemic hyponatremia, and many medications have been associated with SIADH. Pregabalin is a drug used for the treatment of neuropathic pain, though In this review, we will discuss common ASMs associated with hyponatremia, the mechanism of action of various ASMs, clinical symptoms, the presentation of hyponatremia, and treatment strategies for hyponatremia in patients using ASMs. When should gabapentin users seek medical attention for symptoms of hyponatremia? If you have severe symptoms like confusion, seizures, or can't respond, get help right away. View gabapentin information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, monitoring requirements and important safety information. Hyponatremia induced by antiepileptic drugs is common, but detailed evidence is lacking. This can be problematic for the treating neurologist confronted with a patient with severe hyponatremia in need of an alternative drug. To evaluate the risk factors and prevalence of hyponatremia among epilepsy patients in relation to use of antiepileptic drugs (AEDs).We retrospectivel Hyponatremia (defined as a serum sodium level 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients. Certain drugs (eg, diuretics, antidepressants, and antiepileptics) have been implicated as established causes of either asymptomatic or symptomatic hyponatremia. However, hyponatremia occasionally may develop in the course of treatment with drugs used in everyday The most frequent electrolyte disorder in hospitalized patients is hyponatremia [1]. The clinical spectrum in hyponatremia ranges from mild, non-specific symptoms such as fatigue, headache, and gait instability to life-threatening symptoms such as seizures, coma and ultimately death, secondary to brain oedema [2,3]. Pharmaceutical drugs, e.g., thiazide diuretics, antidepressants and In acute symptomatic hyponatremia, hypertonic saline solution (3%) is commonly used to acutely increase serum sodium levels and prevent severe neurologic symptoms (eg, seizures). Hypovolemic hyponatremia is treated with adequate fluid resuscitation to decrease the stimulus for ADH secretion.

neurontin hyponatremia neurontin during pregnancy
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