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Can administration of gabapentin for trigeminal neuralgia dramatically increase liver function tests? In rare cases, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms). Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury have been reported. Though gabapentin has many potential uses, it can cause side effects. Read more about 13 gabapentin side effects here. Gabapentin is eliminated through the kidneys and, therefore, doesn’t typically cause liver injury. Learn safe dosage recommendations for people with liver disease. I found online somewhere that Gabapentin can inflame the liver, yet, also read that it is not metabolized in the liver at all. I read that incidents of liver problems are less than one percent as stated by Pfizer. Gabapentin is not metabolized by the liver. Instead, it is excreted unchanged in your kidneys after circulating in your blood. Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. Similarly, liver issues are uncommon but can occur in dogs with pre-existing liver conditions or those taking other medications that affect liver function. To minimize the risk of organ damage, regular blood work is recommended, especially for dogs on Gabapentin long-term. Gabapentin is an uncommon cause of DILI reported to cause a hepatocellular, cholestatic, or mixed picture of liver injury. Given the limitations of prior cases, we feel our report most closely ties gabapentin use to the resultant transaminase elevation. This article delves deep into the relationship between gabapentin and liver health, exploring mechanisms of action, potential side effects, case studies, and recommendations for monitoring liver function during treatment. Medications like Tylenol and Aleve are hepatotoxic, meaning they could raise liver enzymes and damage your liver over time. See the list of medications to avoid. Learn about the potential effects of Gabapentin on your liver and kidneys. Find out if it is safe to use and how to protect your organs while taking this medication. Can gabapentin cause liver enzymes to be elevated? Gabapentin is a unique anticonvulsant used as an adjunctive therapy in managing epilepsy and neuropathic pain syndromes. It is a structural analogue of gamma-aminobutyric acid (GABA) and has been approved for use in the United States in 1993. It is used as an anticonvulsant and neuropathy agent, with over 18 million prescriptions filled Learn about the side effects of gabapentin, from common to rare, for consumers and healthcare professionals. Liver toxicity is not a common side effect of gabapentin. However, in rare cases, individuals with pre-existing liver conditions or those taking other liver-damaging medications may experience an increased risk of liver-related side effects. Discussion: Gabapentin induced liver injury is rare with few reported cases, many of which did not exclude other etiologies. In this case, the key elements of diagnosing DILI were met including gabapentin initiation closely preceding liver injury, other etiologies excluded, and discontinuation of gabapentin leading to improvement. In rare cases, gabapentin can cause liver and kidney damage in dogs. Dogs with pre-existing liver or kidney disease may be more susceptible to these side effects. Gabapentin is an anti-convulsant that is also used off-label to treat neuropathic pain. It is not metabolized by the liver, and there have been few reports of hepatotoxity associated with it. We present a rare case of gabapentin-induced hepatotoxicity occurring in a young male. Gabapentin was reported to cause cholestasis in two case reports. Despite the small number of reported cases of hepatotoxicity, trazodone and gabapentin are known causes of liver injury, and clinicians should be aware of this possibility. Letters to the Editor Gabapentin-Induced Liver Toxicity Chahal, Japjot MD 1; Arif, Muhammad Osman MD 2; Achufusi, Ted George MD 1 Author Information
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