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Pierce et al.[11] reported a case of gabapentine-in-duced hearing loss in a patient with diabetes melli-tus and acute renal failure, Top et al.[12] have reported to detect sensorineural hearing loss due to gaba-pentin following gabapentin use in the presence of coronary artery disease, diabetes mellitus, and hy-pertension. The effects of gabapentin, 1- (aminomethyl)cyclohexaneacetic acid, on a variety of pain states has been extensively studied in clinical trials. Managing Gabapentin Side Effects and Withdrawal Symptoms Gabapentin is a medication used to treat conditions such as epilepsy, neuropathic pain, and anxiety. While it can be beneficial in treating these symptoms, it can also have some side effects. Some of the more common side effects are drowsiness, dizziness, headache, blurred vision, nausea, and difficulty concentrating. Fortunately, there Areas covered: This article review the evidence that long-term treatment with some antiepileptic drugs (AEDs) [e.g. carbamazepine, phenytoin, valproate, lamotrigine, gabapentin, vigabatrin and oxcarbazepine] (even in therapeutic drug doses) may result in tinnitus, phonophobia, sensorineural hearing loss, dizziness, ataxia, disequilibrium, imbala Answer Tinnitus, or ringing in the ears, is a listed side effect of Neurontin (gabapentin). Interestingly enough, even though gabapentin can cause ringing in the ears, it is sometimes prescribed off-label for the treatment of it. Nevertheless, the vast majority of studies report that the drug is no more effective than placebo in this regard. We report a patient with acute renal failure who developed hearing loss, myoclonus, and confusion with hallucinations in the presence of elevated gabapentin concentrations. Due to rapid improvement after hemodialysis and discontinuation of gabapentin, we believe that these symptoms were probably due Gabapentin is more likely to cause tinnitus (ringing in the ears) than hearing loss – but both have been reported in users. A European Review by Altissimi et al. (2020) reported that gabapentin can induce “tinnitus” and “vertigo or dizziness” – but there was zero documentation of hearing loss & ototoxicity. (R) Summary: Hearing loss is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Zometa, and have Multiple myeloma. The phase IV clinical study analyzes which people have Hearing loss when taking Gabapentin. In addition to gabapentin, other medications, including prescription and herbal supplements, can adversely affect vocal function. Users of gabapentin have reported severe side effects such as double vision, slurred speech, drowsiness, and constipation. At any rate, this could perhaps explain why, in any individual person, gabapentin may be linked to tinnitus even if there is no biological reason why it might be, or not a known or common side effect. Some studies and anecdotal evidence suggest that gabapentin might exacerbate tinnitus symptoms for certain individuals, potentially due to its effects on the auditory system and neurotransmitter modulation. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. Gabapentin may cause vision changes, clumsiness, unsteadiness, dizziness, drowsiness, sleepiness, or trouble with thinking. Purpose The main aim of this study was to assess the effect of gabapentin on tinnitus via a systematic review. Method An electronic search of l In fact, Gabapentin is quite ototoxic. According to the PDR, it can cause hearing loss, hyperacusis, tinnitus, ataxia, dizziness, vertigo, and ear pain among other things. This is not the kind of drug you want doctors using to treat your ears, or anywhere in your body for that matter! Gabapentin can lead to reversible hearing impairment, especially in renal-impaired individuals. Mechanisms include toxic effects on cochlear hair cells and interference with neurotransmitter release. Risk factors include impaired renal function, prolonged high-dose use, and acute renal failure. In this study, we evaluated the effect of gabapentin on the sensation of subjective tinnitus in patients with acoustic trauma referring to the ear, nose and throat (ENT) clinic of Taleghani Hospital during 2014. Materials and Methods: Though gabapentin has many potential uses, it can cause side effects. Read more about 13 gabapentin side effects here. Controlled clinical trials investigating the effects of gabapentin on tinnitus have produced inconsistent results, with some studies suggesting a placebo effect and others indicating improvement with gabapentin use. Gabapentin is a FDA-approved medication used in humans to treat chronic pain in dogs, particularly neuropathic pain. Its most common side effects in dogs include sedation and ataxia (loss of coordination), which can cause sleepiness, lethargicness, or reduced coordination. Serious side effects are rare but can occur, such as seizures and difficulty breathing. Those with 12 or more gabapentin prescriptions were 40% more likely to develop dementia and 65% more likely to develop MCI than those prescribed the drug three to 11 times. Researchers noted that because this is an observational study, it cannot draw a direct cause-and-effect association between gabapentin and brain decline.
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