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The bad effects of gabapentin in our study come in line with previous studies done by [12, 13,14,15] and 16). Gabapentin caused elevated liver function enzymes AST, ALT, and ALP beside bilirubin. Gabapentin is a unique anticonvulsant that is used as adjunctive therapy in management of epilepsy and for neuropathic pain syndromes. Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from gabapentin have been rep Unveiling Gabapentin's Potential Impact on Liver Health Gabapentin is a widely prescribed medication, primarily known for its efficacy in managing seizures and neuropathic pain. Understanding its potential effects, especially concerning liver health, is paramount. This exploration delves into the intricacies of gabapentin's interaction with the Introduction: Gabapentin is an anti-convulsant that is also used off-label to treat neuropathic pain. It is not metabolized by the liver, and there have been few reports of hepatotoxity associated with it. We present a rare case of gabapentin-induced hepatotoxicity occurring in a young male. Case Description/Methods: A 41-year-old male with an extensive past medical history including type 1 Gabapentin (GPN) is a new antiepileptic agent currently in used as add-on therapy in adult patients suffering from partial seizures. The extent of liver damage at different dosage and long term treatment with GPN is not yet clear. Therefore this study was undertaken to find out the possibility of li Gabapentin use isn’t known to affect enzyme or bilirubin levels, but it may rarely cause an allergic reaction characterized by elevated eosinophil levels. This is a condition called eosinophilia, which may cause liver damage. Clinical findings showed that gabapentin led to significant elevation of liver enzymes (ALT, AST, and GGT) and bilirubin levels while other causes of viral hepatitis were excluded (7). Learn about the side effects of Neurontin (gabapentin), from common to rare, for consumers and healthcare professionals. Antiepileptic drugs (AEDs) are a common cause of drug induced liver injury (DILI). Over the last few decades, several newer AEDs were approved for marketing in the United States, and they are increasingly prescribed for indications other than A review of the patient’s record shows he had normal transaminase, total bilirubin, and alkaline phosphatase levels one week prior (Table 1). On further questioning, the patient mentioned that he was started on gabapentin 300 milligrams twice a day exactly one week prior (05/19/2017) for diabetic neuropathy. Gabapentin (GPN) is a new antiepileptic agent currently in used as add-on therapy in adult patients suffering from partial seizures. The extent of liver damage at different dosage and long term Can gabapentin cause liver enzymes to be elevated? Gabapentin is a unique anticonvulsant used as an adjunctive therapy in managing epilepsy and neuropathic pain syndromes. It is a structural analogue of gamma-aminobutyric acid (GABA) and has been approved for use in the United States in 1993. The figure above depicts the patient’s trend in alkaline phosphatase and total bilirubin starting at a baseline obtained 2 years prior to initiation of gabapentin through to his discharge (one month after gabapentin was stopped). The x-axis show chronology of gabapentin administration. The left y-axis shows alkaline phosphatase levels in IU/L. Gabapentin is generally considered safe for the liver, but rare cases of liver damage have been reported. Gabapentin, a medication primarily used to treat nerve pain and seizures, has gained popularity for its effectiveness and relatively mild side effects. Abstract- Gabapentin (GPN) is a new antiepileptic agent currently in used as add-on therapy in adult patients suffering from partial seizures. The extent of liver damage at different dosage and long term treatment with GPN is not yet clear. Therefore this study was undertaken to find out the possibility of liver damage by this drug. Adult male (Wistar) rats of 180-220 g were administered The levels of total bilirubin and conjugated bilirubin in serum (A) and the brain-to-plasma concentration ratio of gabapentin in the cortex, hippocampus, and striatum (B). Gabapentin induced cholestasis was thought likely and the drug was stopped. After this, clinical symptoms and liver function tests improved gradually (figure). A liver biopsy showed normal liver architecture with evidence of portal tract expansion by a chronic inflammatory cell infiltrate that incorporated eosinophils and neutrophils. Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. There is insufficient data to estimate incidence for these or establish whether gabapentin is the sole cause of elevated liver function tests, notes Pfizer. Gabapentin was reported to cause cholestasis in two case reports. Despite the small number of reported cases of hepatotoxicity, trazodone and gabapentin are known causes of liver injury, and clinicians should be aware of this possibility. The man's treatment with gabapentin was discontinued and his liver enzymes started to downtrend with discharge values of AST 16, ALT 35, ALP 413, total bilirubin 9.3 and INR 1.1.
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