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The association between gabapentin or pregabalin exposure and dementia risk was further examined with stratification according to sex, age, and comorbidities such as diabetes, hypertension, stroke, dyslipidemia, depression, and head injury. Key takeaways: Certain medications are linked to an increased risk of dementia. But that doesn’t mean they necessarily cause dementia. Medications that have been associated with increased risk of dementia include overactive bladder medications, pain medications, heartburn medications, and certain anxiety medications. The risk of dementia with these medications increases when you take higher According to a large scale observational study published in the journal "Regional Anesthesia & Pain Medicine", patients who received frequent gabapentin prescriptions were significantly more likely to develop dementia and/or mild cognitive impairment (MCI). Researchers analyzed anonymized medical records from tens of thousands of Americans sourced from TriNetX, a federated health research To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)--29% and 85 Background Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. Howev A large U.S. medical records study has found that adults prescribed gabapentin six or more times for chronic low back pain face significantly higher risks of dementia (29%) and mild cognitive impairment (85%) within 10 years. Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. A recent study has linked gabapentin, a popular painkiller for lower back pain, to increased risk of dementia and mild cognitive impairment in some adults. Frequent use of common pain drug linked to increase in dementia and cognitive decline, study suggests. Common Pain Drug Gabapentin Linked To Dementia Diagnoses In Adults Research shows that patients with six or more prescriptions for gabapentin, commonly used to treat lower back pain, were 29% more likely to be diagnosed with dementia and 85% more likely to be diagnosed with mild cognitive impairment within 10 years of their initial pain diagnosis. Gabapentin (Neurontin) prescriptions for chronic low back pain were linked with an increased risk of dementia and cognitive impairment, especially in younger people, an analysis of U.S. healthcare Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine. Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine. What’s more, the risk was more than doubled in people normally considered too young to suffer from brain aging, those 18 to 64, results show. Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and Gabapentin, which is used to treat seizures, nerve pain and restless leg syndrome might be linked with increased risk of dementia, a new study says. An extremely popular nerve pain drug commonly given to those suffering from low-back issues has been linked to impaired mental health including dementia and mild cognitive impairment. The risk was Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain. Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024 Gabapentin new users with normal cognition at the visit of gabapentin initiation (i.e., index visit) were included. New-users were matched on year of first enrollment and time of gabapentin initiation since enrollment to randomly select nonusers with replacement.
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