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Gabapentin might lower levels of folic acid in people who take this medication. Some professional organizations recommend that people on this type of medication take a higher dose of folic acid, while other groups do not. A phase IV clinical study of FDA data: drug interactions are found among 7,597 people who take Gabapentin (gabapentin) and Folic acid (folic acid). A study from the European Gabapentin Registry included prospective and retrospective data with a total of 51 outcomes and 44 live births of women with epilepsy and other disorders exposed to gabapentin during pregnancy. Gabapentin might lower levels of folic acid in women who take this medication. Some professional organizations recommend that women on this type of medication take a higher dose of folic acid, while other groups do not. Talk with your healthcare provider about how much folic acid is right for you. Please see our MotherToBaby fact sheet and baby blog on folic acid/folate at When treating neuropathic pain in a woman who is pregnant, the use of gabapentinoids (e.g. gabapentin) or an antiepileptic drug (AED) (e.g. levetiracetam, lamotrigine) is a last line option. This is due to the limited availability of data for safe use during pregnancy. Other options should be trialled first. These include: non-pharmacological therapies (e.g. physical therapy), topical agents Data collected included: maternal demographics (age, education level); maternal diagno-sis for which gabapentin was prescribed (epilepsy, pain, or mood disorder); epilepsy seizure type; AEDs taken at the time of conception and at the time of delivery; multivitamin/folic acid use prior to and within 6 weeks of conception; use of oral contracep Gabapentin is an anti-seizure drug and some of these can affect folic acid levels. Women taking gabapentin while trying to conceive and during pregnancy should therefore be prescribed a high dose folic acid supplement (5mg/day). Comments: -The risk of having a child with a congenital defect as a result of antiepileptic medication is far outweighed by the dangers to the mother and fetus of uncontrolled epilepsy; folic acid supplementation (5 mg) should be started 4 weeks prior to and continued for 12 weeks after conception. Potential interaction with nutrients: Gabapentin may interact with certain vitamins and minerals, like folic acid, which is essential for a healthy pregnancy, reducing the levels of these nutrients. Gabapentin is a Pregnancy Category C drug and Animal studies suggest that it can harm an unborn child and therefore should be avoided during pregnancy. Gabapentin might lower levels of folic acid in women who take this medication. Some professional organizations recommend that women on this type of medication take a higher dose of folic acid, while other groups do not. Talk with your healthcare provider about how much folic acid is right for you. Please see our MotherToBaby fact sheet and baby blog on folic acid/folate at Gabapentin is an anti-seizure drug and some of these can affect folic acid levels. Women taking gabapentin while trying to conceive and during pregnancy should therefore be prescribed a high dose folic acid supplement (5mg/day). UK guidelines state that women who take any anti-epileptic medication should be prescribed high dose folic acid (5mg), although it is currently not known whether high dose folic acid supplementation offers any additional benefit or protective effects over standard dose regimes when taking gabapentin preconceptually or during pregnancy. Expert insights on gabapentin and pregnancy safety considerations. Learn about risks, benefits, and medical recommendations for managing this medication during pregnancy. Gabapentin might lower levels of folic acid in women who take this medication. Some professional organizations recommend that women on this type of medication take a higher dose of folic acid, while other groups do not. Talk with your healthcare provider about how much folic acid is right for you. Please see our MotherToBaby fact sheet and baby blog on folic acid/folate at The USPSTF recommends that all women who are planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400 to 800 µg) of folic acid. Gabapentin and fertility There's no evidence to suggest that taking gabapentin reduces fertility in either men or women. However, discuss your pregnancy plans with a doctor. They may wish to review your medicine and prescribe a higher dose of folic acid for you to take (5mg a day) before you become pregnant. Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes. It is recommended that all women taking anti-epileptic medicines also take high dose folic acid (5mg/day) whilst trying to conceive and during the first trimester of pregnancy. High dose folic acid has to be prescribed by a doctor. For more information, please see the folic acid bump leaflet.
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