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Is gabapentin safe during pregnancy? Learn about the potential risks and benefits of taking gabapentin while pregnant, and what you should discuss with your doctor. Because the risks of taking gabapentin while pregnant in humans are not fully understood, use of gabapentin during pregnancy is determined on a case-by-case basis to determine if the benefits outweigh the risks. Gabapentin is a pregnancy category C, which means risk cannot be ruled out. Does gabapentin cause birth defects? Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. Gabapentin and Pregnancy - Gabapentin - GabapentinTo provide information regarding the effects of in utero exposure to gabapentin, physicians are advised to recommend that pregnant patients taking gabapentin enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. How Gabapentin Can Be Addictive Mechanism: Gabapentin affects the brain’s neurotransmitters, particularly by While gabapentin (Neurontin) is now used in a wide variety of clinical settings — for epilepsy, pain management, restless leg syndrome, anxiety, and sleep disturbance – there is relatively little information regarding its reproductive safety. Most recently, a prospective study from researchers at the Motherisk program reports on the outcomes of 223 pregnancies exposed to gabapentin With maternal doses up to 2.1 g/day, estimated doses for fully breastfed infants are 0.2 to 1.3 mg/kg/day (equivalent to 1.3 to 3.8% of the maternal weight-adjusted dose). An expert panel has deemed this drug is an acceptable choice for refractory restless leg syndrome during lactation. As a precaution, gabapentin is only prescribed in pregnancy when the benefits (most commonly of controlling seizures in women with epilepsy) outweigh the possible risks. Gabapentin is an anti-seizure drug and some of these can affect folic acid levels. This sheet discusses gabapentin use during pregnancy and breastfeeding, offering guidance on potential risks and safety considerations. Women who are pregnant should ask their doctor if they can take gabapentin while pregnant. Doctors also consider the risk during pregnancy if a woman is trying to conceive or is currently in the early stages. The baby’s safety is first, hence every matter should be treated carefully. Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset. A study from the European Gabapentin Registry included prospective and retrospective data with a total of 51 outcomes and 44 live births of women with epilepsy and other disorders exposed to gabapentin during pregnancy. Methods A systematic review was performed in PubMed and Reprotox using the search terms: “gabapentin”, “pregabalin”, “antiepileptic drugs” and terms associated with pregnancy. We included all studies in English that reported on the use and safety of gabapentin and pregabalin during pregnancy. In a cohort study of pregnant women included in the US Medicaid Analytic eXtract (MAX) dataset, Elisabetta Patorno and colleagues investigate neonatal and maternal outcomes associated with gabapentin exposure during pregnancy. This article summarizes the current literature regarding gabapentin use during pregnancy and related prenatal and neonatal exposure outcomes with special consideration for interactions between gabapentin and opioid use. Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes. There's no evidence to suggest that taking gabapentin reduces fertility in either men or women. However, discuss your pregnancy plans with a doctor. They may wish to review your medicine and prescribe a higher dose of folic acid for you to take (5mg a day) before you become pregnant. It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among women who take gabapentin. There was an increased risk of preterm birth among women exposed to gabapentin either late (RR=1.28 [CI 1.08-1.52], p < 0.01) or both early and late in pregnancy (RR=1.22 [1.09-1.36], p < 0.001). Data on gabapentin use in pregnancy are mixed—some studies suggest it can result in increases in birth defects and other pregnancy complications, while other studies suggest it’s safe. In this large population-based study, we did not find evidence for an association between gabapentin exposure during early pregnancy and major malformations overall, although there was some evidence of a higher risk of cardiac malformations. Maternal use of gabapentin, particularly late in pregnancy
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