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Various non-hormonal agents have been used for the treatment of hot flashes in women with menopause. Some studies have reported that gabapentin appears to be an effective and well-tolerated treatment modality. The aim of this study was to evaluate Navigating menopause can be challenging, with symptoms like hot flashes, mood swings, and sleep disturbances affecting daily life. While hormone replacement therapy is a common treatment, some women seek alternatives. Gabapentin, traditionally used for nerve pain, has emerged as a promising option for managing menopaus Buy SDC Metrics Abstract Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. Methods: This study revealed that without consideration of the type of sleep outcomes, gabapentin was significantly superior to placebos for the treatment for sleep disorders secondary to RLS, neuropathic pain, alcohol dependence, hot flashes in menopause, fibromyalgia, phantom limb pain, HIV-associated sensory neuropathies, and bipolar disorder. Gabapentin may improve sleep quality in menopausal women with hot flashes. These results warrant further prospective investigation, with an emphasis on measuring subjective sleep quality and maintenance. An investigational nonhormonal drug, extended-release gabapentin, effectively improved sleep and reduced hot flashes in menopausal women. Introduction Research of women’s views confirms that many women will look for non-hormonal or alternative treatments to help manage menopause symptoms, rather than seek medical help.1 Some women cannot take hormonal therapies and greater experience working with women who have had breast cancer2-4 provides better evidence as to how best to manage these patients with an individualised holistic Gabapentin is a medication you might have heard about for treating seizures or nerve pain, but it’s also gaining attention as a helpful option for women dealing with menopause symptoms—especially hot flashes and trouble sleeping. When women go through menopause, their bodies produce less estrogen. Insomnia related to nighttime awakenings is known to be more prevalent in women than men. Three cases are presented here of late premenopausal women experiencing frequent nighttime awakenings that responded well to bedtime treatment with gabapentin. The journey through menopause is unique for each woman, and so too should be the approach to managing its symptoms, including sleep disturbances. By combining medical interventions like gabapentin with holistic lifestyle changes and alternative therapies, many women can find relief from the sleep issues that often accompany this transitional Gabapentin 300 mg at bedtime (qhs) was initiated in 9/2006, based on evidence of efficacy in the treatment of hot flashes and night sweats 5 – 7 and improved sleep in such patients. 8 The patient experienced benefit after the first dose of gabapentin, reporting a full night's sleep without any awakenings or night sweats. About 80% of postmenopausal women experience vasomotor symptoms, such as hot flashes and night sweats – symptoms that are associated with sleep disruption and can lead to fatigue and mood changes. Moreover, hot flashes can be embarrassing for women, Gabapentin (Neurontin): Often used for nerve pain or seizures. It can help reduce nighttime hot flashes and improve sleep. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep NATIONAL HARBOR, MD. – Extended-release gabapentin at daily doses of either 1,200 mg or 1,800 mg significantly reduced the number and severity of hot flashes and significantly improved sleep problems, compared with a placebo, in postmenopausal women. Vasomotor symptoms are common among postmenopausal women and patients receiving hormone deprivation therapies, and emerging studies are exploring gabapentin’s and pregabalin’s effects as nonhormonal treatment options. We aimed to assess the efficacy and safety of these 2 drugs. A drug approved for seizure control that is also commonly used to treat pain was found in a preliminary study to significantly improve sleep quality in postmenopausal women, with few adverse effects. HRT is the current go-to treatment for menopausal hot flashes. Gabapentin offers non-hormonal relief and reduction in hot flashes and night sweats. 3. Sleep Disturbance across Menopause: Epidemiology Middle-aged women have increasing complaints of sleep disorders as they enter menopausal transition and the menopausal period. The incidence rates of sleep problems show 39–47% in peri-menopausal and 35–60% in postmenopausal women, compared to 16–42% in premenopausal women [3].
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