I was doing some research on Gabapentin (Neurontin) and was wondering if anyone out there has any intel on it? The below study claims it has little to no effect compared to placebo. But I have heard some encouraging results elsewhere. Any thoughts? Relief of Idiopathic Subjective Tinnitus - Tinnitus UK try very hard to make sure our information is right, but this information should not be taken as medical advice. You should always check with your doctor before trying any tinnitus treatment. Gabapentin is a commonly-used medication for the treatment of neuropathic pain (e.g. peripheral neuropathy), restless leg syndrome, and seizure prevention & management – as well as other conditions like anxiety disorders & substance use disorders (off-label). Although many find gabapentin effective as a treatment for the aforementioned medical conditions, some are concerned about the drug The authors of both studies reported that gabapentin was not superior to placebo in their primary outcomes. However, following the assessment of risk of bias and within-study clinical heterogeneities, this review concludes that there is insufficient evidence regarding the effect of gabapentin on tin International Tinnitus Journal, Vol. 14, No. 1, 1–5 (2008) - Gabapentin and Tinnitus Relief This article is an editorial reply on the JAMA Network report above. Gabapentin is effective in reducing subjective and objective aspects of tinnitus in some individuals, with the best therapeutic response obtained in individuals with associated acoustic trauma. Subjective tinnitus, the phantom ringing or buzzing sensation that occurs in the absence of sound, affects 12–14% of adults; in some cases the tinnitus is so severe or disabling that patients seek medical treatment. However, although the economic The hypothesis was that gabapentin would decrease both subjective and objective features of tinnitus in the trauma group but would be less effective in the nontrauma group. Study Design: Prospective, placebo-controlled, single-blind clinical trial. Despite the positive results of gabapentin in the treatment of tinnitus, reports of the investigations are conflicting and most recommend further randomized clinical trials in order to evaluate the impact of gabapentin on tinnitus. The Connection Between Gabapentin and Tinnitus Gabapentin, a medication primarily used to treat neuropathic pain and seizures, has gained attention for its potential side effects, particularly concerning auditory health. Tinnitus, characterized by the perception of noise or ringing in the ears without an external sound source, affects millions worldwide. Understanding whether gabapentin can The Gabapentin Story – As an Example Arguably, one of the drugs that has been studied most extensively as a tinnitus treatment is gabapentin (marketed as Neurontin®). It is useful to look at the history of this drug to appreciate the promise and pitfalls encountered when searching for effective tinnitus treatments. Gabapentin was developed and FDA-approved for use as an adjunct medication In this article, the author describes the case of a patient with tinnitus who was successfully treated with the antiepileptic medication gabapentin. Although tinnitus has a prevalence between 20 and 42.8%, the currently recommended management for tinnitus, such as tinnitus support and psychologic therapies, are relatively time-consuming and expensive. Several new pharmacologic treatments designed for tinnitus patients without specific origin had been developed but their efficacy remains unclear. Claims for treatment That anticonvulsants potentially reduce central auditory hyperactivity that may be related to tinnitus [1]. What is the treatment? Gabapentin is taken in pill or capsule form. What are the downsides of this treatment? Common side effects from clinical trials included nausea, dizziness, headache, tiredness [2]. Has there been research into this treatment? Yes, although very Tinnitus, or ringing in the ears, is a listed side effect of Neurontin (gabapentin). Interestingly enough, even though gabapentin can cause ringing in the ears, it is sometimes prescribed off-label for the treatment of it. Why should we not be surprised? After all, Gabapentin causes tinnitus in a good number of the people that take it. In fact, Gabapentin is quite ototoxic. According to the PDR, it can cause hearing loss, hyperacusis, tinnitus, ataxia, dizziness, vertigo, and ear pain among other things. Sage Journals: Your gateway to world-class journal research Enter gabapentin, a medication that has been associated with tinnitus, among its various side effects. In this article, we will delve deep into the intricate relationship between gabapentin and tinnitus, exploring the factors that influence tinnitus risk with gabapentin use. Her tinnitus was abolished after an administration of a low dose of gabapentin. In view of a controversy of gabapentin and tinnitus in previous trials, the fi ndings in this patient support that low dose gabapentin can benefi t specifi cally the subgroup of tinnitus patient with sensorineural impairment due to secondary contributing factor. Gabapentin and Tinnitus Relief This editorial and commentary was prompted by the publication of Picirillo et al.’s “Relief of id-iopathic subjective tinnitus: Is gabapentin effec-tive?” [1], which concluded that gabapentin was no more effective than a placebo in relieving tinnitus. The goal of this editorial and commentary is constructive: to provide to tinnitus patients and
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