To the Editor: Sexual dysfunction is an unfortunate side effect of many medications, including those used to treat common psychiatric and neurologic disorders. Gabapentin, a medication used widely in the treatment of epilepsy, neuropathic pain, and bipolar disorder, is generally well tolerated. To our knowledge, only four definite (1 – 4) and three possible (5) cases of gabapentin-induced This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation, anorgasmia, and impotence) at a total daily dose of only 300 mg. There may be different gabapentin side effects in women than in men. Learn why dizziness, tiredness, and other side effects may occur and how to prevent them. The mechanism of action of gabapentin is unknown, and the effects on ejaculation or other aspects of sexual function are also unknown. As gabapentin becomes more commonly used in psychiatric practice, the frequency of this adverse effect may become more apparent. Low-dose gabapentin may result in marked sexual dysfunction, including loss of libido, erectile dysfunction, ejaculatory dysfunction, and anorgasmia. Such sexual dysfunction may lead to medication noncompliance. Sexual dysfunction is a key adverse effect leading to medication noncompliance. Psychotropic drugs associated with sexual dysfunction include antiepileptic drugs, antidepressants, and antipsychotics. Gabapentin, frequently used off-label to treat psychiatric and pain disorders, has previously been reported to cause sexual dysfunction at a minimum total daily dose of 900 mg. This report Gabapentin could cause erectile dysfunction, sexual desire changes and ejaculatory dysfunction. There’s evidence that gabapentin may affect a man’s ability to reach orgasm (either by causing premature ejaculation or delayed ejaculation), especially if he’s older. An estimated 1-5% of gabapentin users may have some sexual side effects and the true frequency may be limited due to underreporting. Reduced libido and erectile dysfunction (ED) are the most commonly reported issues. There may be sexual side effects of gabapentin, but they’re not very common and are treatable. Gabapentin is an anticonvulsant medication that’s FDA approved to treat partial-onset seizures, postherpetic neuralgia, and restless leg syndrome. Erectile dysfunction is a known side effect of gabapentin, a common anti-epileptic. This is what you need to know about gabapentin and ED. Gabapentin can cause ED as a side effect, but it’s important to understand that not everyone who takes it will experience this side effect. ED is listed as a potential side effect in the prescribing information for Gabapentin, along with other sexual dysfunction issues like decreased libido and ejaculatory and orgasmic dysfunctions. This case demonstrates a clear on/off phenomenon of anorgasmia related to gabapentin, which may be dose related. The frequency of this adverse effect is unknown, although sexual side effects were reported as uncommon in clinical trials when epilepsy was treated. In men, Gabapentin is associated with sexual dysfunction. Men who use the medication have a high incidence of anorgasmia or difficulty in achieving an orgasm. Gabapentin-induced sexual dysfunction is common in older men. When your doctor prescribes Gabapentin they should advise you about the side effects. Related topics gabapentin, sex Further information Gabapentin uses and safety info Gabapentin prescribing info & package insert (for Health Professionals) Side effects of Gabapentin (detailed) Similar questions Search for questions Still looking for answers? Try searching for what you seek or ask your own question. ED caused by gabapentin is a potential side effect. Additionally, research shows several medications used for treating epilepsy can cause sexual dysfunction in both men and women. Studies on gabapentin’s sexual side effects have shown that sexual dysfunction caused by this medication in both men and women was resolved when their doses were reduced or when their medications were changed. One 52-year old man experienced ED while taking 900 to 1,500 mg of gabapentin. Common adverse effects include somnolence, dizziness, fatigue, and peripheral edema; sexual side effects, including anorgasmia, have been rarely described in patients with psychiatric illness and neuropathic pain [8–10]. Sexual dysfunction is a key adverse effect leading to medication noncompliance. Psychotropic drugs associated with sexual dysfunction include antiepileptic drugs, antidepressants, and antipsychotics. Gabapentin, frequently used off-label to treat psychiatric and pain disorders, has previously been reported to cause sexual dysfunction at a minimum total daily dose of 900mg. This report Gabapentin is used for dogs and is commonly prescribed by veterinarians to treat seizures, pain, and anxiety in dogs. It has a low risk of side effects. Continue reading
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